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4-Phenylbicyclo[2.2.2]octan-1-amine

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Identification
Molecular formula
C14H19N
CAS number
127108-49-4
IUPAC name
4-phenylbicyclo[2.2.2]octan-1-amine
State
State

The compound is in a solid state at room temperature under normal conditions, frequently appearing as a crystalline powder that can be handled as a typical solid in laboratory environments.

Melting point (Celsius)
111.00
Melting point (Kelvin)
384.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
187.31g/mol
Molar mass
187.2800g/mol
Density
1.0970g/cm3
Appearence

4-Phenylbicyclo[2.2.2]octan-1-amine is typically a white to off-white crystalline solid. This compound is distinct in its structural complexity due to the bicyclo[2.2.2]octane system attached to a phenyl group, providing it a unique framework that is often explored in chemical syntheses and reactions.

Comment on solubility

Solubility Characteristics of 4-phenylbicyclo[2.2.2]octan-1-amine

The solubility of 4-phenylbicyclo[2.2.2]octan-1-amine can be quite intriguing due to its unique bicyclic structure. Generally, the solubility of such compounds can vary based on several factors:

  • Polarity: The presence of amine functional groups typically increases the polarity of the molecule, potentially enhancing solubility in polar solvents.
  • Hydrogen Bonding: The amine group may facilitate hydrogen bonding with solvents, contributing to solubility in water and other hydrogen-bonding solvents.
  • Hydrophobic Regions: The bicyclic structure contains hydrophobic aromatic components, which might reduce solubility in polar solvents.
  • Temperature Dependent: The solubility characteristics of this compound might change with temperature; often, higher temperatures can increase solubility.

In summary, one may find that 4-phenylbicyclo[2.2.2]octan-1-amine has variable solubility behavior. It is essential to consider the solvent nature and environmental conditions when assessing its solubility profile:

  1. In polar solvents: Moderately soluble due to hydrogen bonding.
  2. In organic solvents: Solubility might vary widely, influenced by the solvent’s ability to interact with both the hydrophobic and hydrophilic parts of the molecule.

Understanding these dynamics is vital for practical applications in pharmaceutical and material sciences.

Interesting facts

Interesting Facts about 4-phenylbicyclo[2.2.2]octan-1-amine

4-phenylbicyclo[2.2.2]octan-1-amine is a fascinating compound that belongs to the class of amines, which play a crucial role in organic chemistry and biochemistry. Here are some intriguing aspects of this compound:

  • Structural Diversity: The bicyclic structure of 4-phenylbicyclo[2.2.2]octan-1-amine contributes to its unique properties. Bicyclic compounds often exhibit interesting strain and flexibility in their molecular structure, which can influence reactivity and interactions.
  • Pharmacological Potential: Compounds with amine functional groups are often investigated for their biological activity. This particular compound could have implications in the development of new pharmaceuticals, particularly in targeting various receptor systems in the body.
  • Applications in Synthesis: The bicyclic framework can serve as a valuable intermediate in organic synthesis, allowing for the construction of more complex molecules. Its unique structure can facilitate various chemical reactions, including substitutions and rearrangements.
  • Catalytic Properties: There is ongoing research into how bicyclic amines like 4-phenylbicyclo[2.2.2]octan-1-amine might act as catalysts in chemical reactions. Their unique geometry could potentially offer new pathways for catalytic cycles.

In summary, the study of 4-phenylbicyclo[2.2.2]octan-1-amine is not only a journey into specialized organic chemistry, but it also opens doors to potential applications in medicine and synthetic chemistry. As with many compounds in this class, ongoing research may uncover even more exciting uses as we delve deeper into their properties and interactions.

Synonyms
10206-89-0
Exp 561
4-Phenylbicyclo[2.2.2]Octan-1-amine
Exp561
Bicyclo(2.2.2)octan-1-amine, 4-phenyl-
1-Amino-4-phenylbicyclo(2.2.2)octane
1P958G9T1V
4-Phenylbicyclo(2.2.2)octan-1-amine
EXP-561
DTXSID20144571
Bicyclo[2.2.2]octan-1-amine, 4-phenyl-
DTXCID4067062
6S9H885MKF
Bicyclo(2.2.2)octan-1-amine, 4-phenyl-, hydrochloride
Bicyclo(2.2.2)octan-1-amine, 4-phenyl-, hydrochloride (1:1)
CHEMBL288524
4-Phenyl-bicyclo[2.2.2]oct-1-ylamine
UNII-1P958G9T1V
(4-phenyl-1-bicyclo[2.2.2]octanyl)azanium chloride
SCHEMBL11046911
JXMVQBDHMBOHDH-UHFFFAOYSA-N
BDBM50022781
1-amino-4-phenylbicyclo[2,2,2]octane
4-Phenylbicyclo[2.2.2]oct-1-ylamine #
(EXP-561)4-Phenyl-bicyclo[2.2.2]oct-1-ylamine
Q5324704