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TFMPP (3-Trifluoromethylphenylpiperazine)

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Identification
Molecular formula
C18H23N2O4
CAS number
15532-75-9
IUPAC name
(4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, TFMPP is in a solid state.

Melting point (Celsius)
127.50
Melting point (Kelvin)
400.65
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
330.37g/mol
Molar mass
330.3730g/mol
Density
1.2430g/cm3
Appearence

TFMPP is typically a crystalline solid that can appear white to off-white in color. It is often found as a powder for research and study purposes.

Comment on solubility

Solubility of (4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

The solubility characteristics of (4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone can be intriguing due to its complex structure. When evaluating the solubility of this compound, several factors must be considered:

  • Polarity: The presence of multiple methoxy groups in the structure may contribute to hydrophilicity, which can enhance solubility in polar solvents.
  • Solvent Compatibility: This compound is more likely to be soluble in organic solvents such as ethanol or methanol compared to water, owing to its largely non-polar aromatic components.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, making it essential to consider the impact of heat during dissolution.
  • pH Effects: The solubility may also vary under different pH conditions, potentially influencing ionization states which can affect solubility in aqueous solutions.

In summary, while the solubility of (4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone can be moderate in certain organic solvents, it is generally limited in water. Always consider both chemical structure and the environment when studying solubility, as these interact to dictate the behavior of compounds in various media.

Interesting facts

Interesting Facts about (4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

The compound (4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone, often referred to in scientific literature, is a fascinating molecule that has gained attention in various fields of research. Here are some intriguing aspects:

  • Structure and Function: The structural features of this compound include a piperazine ring and a methanone group, contributing to its potential biological activity. The presence of methoxy groups enhances its pharmacological properties by influencing receptor interactions.
  • Pharmaceutical Significance: Compounds that incorporate piperazine moieties are often explored in medicinal chemistry for their ability to modulate neurotransmitter systems. This molecule might play a role in the development of new therapeutics targeting mental health disorders.
  • Research Applications: Due to its unique structure, it has been investigated for its antidepressant and anxiolytic effects, illustrating its potential use in treating anxiety-related conditions. Studies often focus on how structural modifications can refine these properties.
  • In Silico Studies: Computational chemistry techniques are frequently utilized to model the interactions of this compound with various biological targets. This approach helps in predicting how changes in the structure can enhance efficacy or reduce side effects.
  • Synthesis Pathways: The synthesis of this compound often involves multi-step chemical reactions, showcasing the complexities and challenges that arise in organic synthesis. It offers a good case study in the importance of reaction conditions and reagent choice.

In summary, (4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone is more than just a chemical entity; it represents the intersection of structural chemistry and pharmacology. Its ongoing research continues to unveil its potential applications in drug development and therapeutic interventions.

Synonyms
1-Phenyl-4-(3,4,5-trimethoxybenzoyl)piperazine
17766-63-1
BRN 0763988
4-Phenylpiperazinyl 3,4,5-trimethoxyphenyl ketone
KETONE, 4-PHENYLPIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
Piperazine, 1-phenyl-4-(3,4,5-trimethoxybenzoyl)-
DTXSID60170359
5-23-01-00170 (Beilstein Handbook Reference)
DTXCID7092850
(4-phenylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
Oprea1_700390
Oprea1_785459
(4-phenylpiperazin-1-yl)(3,4,5-trimethoxyphenyl)methanone
STK090561
AKOS000577094
ST055457
SR-01000512727
SR-01000512727-1
BRD-K23100884-001-01-5