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4-Phenylpyrimidine

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Identification
Molecular formula
C10H8N2
CAS number
1611-49-4
IUPAC name
4-phenylpyrimidine
State
State

At room temperature, 4-Phenylpyrimidine is typically found in a solid state. It is stable under normal conditions and should be stored in a cool, dry place to prevent degradation.

Melting point (Celsius)
73.00
Melting point (Kelvin)
346.15
Boiling point (Celsius)
281.00
Boiling point (Kelvin)
554.15
General information
Molecular weight
155.18g/mol
Molar mass
155.1830g/mol
Density
1.0912g/cm3
Appearence

4-Phenylpyrimidine is a colorless to pale yellow crystalline solid. It often appears in the form of small crystals or a powder, depending on the method of preparation and purity. It has a characteristic aromatic odor.

Comment on solubility

Solubility of 4-phenylpyrimidine

4-phenylpyrimidine, with the chemical formula C11H9N2, displays intriguing solubility characteristics in various solvents. Here's what you need to know:

  • Polar Solvents: 4-phenylpyrimidine is typically insoluble in water due to its nonpolar hydrocarbon structure. Its minimal interaction with polar molecules limits its solubility.
  • Nonpolar Solvents: On the other hand, 4-phenylpyrimidine shows much better solubility in organic solvents such as ethanol, chloroform, and ethyl acetate. These solvents can effectively solvate the compound's hydrophobic regions.

The differential solubility profiles can be attributed to the following factors:

  1. Molecular Structure: The presence of a phenyl group enhances hydrophobic interactions, which favors solubility in nonpolar media.
  2. Temperature Dependence: As is common with many organic compounds, solubility may exhibit a temperature dependence; increasing temperature can enhance solubility in nonpolar solvents.

In summary, while 4-phenylpyrimidine is insoluble in water, it readily dissolves in a variety of organic solvents. This knowledge is crucial for practical applications in pharmaceuticals and organic synthesis, where solvent choice is vital for successful reactions and extractions.

Interesting facts

Interesting Facts about 4-Phenylpyrimidine

4-Phenylpyrimidine is a fascinating organic compound known for its diverse applications in various fields of chemistry and materials sciences. Here are some intriguing facts about this compound:

  • Structural Significance: The compound features a pyrimidine ring, which is a six-membered aromatic heterocycle containing two nitrogen atoms at positions 1 and 3. This unique structural framework contributes to its reactivity and interactions with other chemical species.
  • Biochemical Relevance: 4-Phenylpyrimidine and its derivatives are often studied for their potential biological activities. Some research indicates that they may serve as important scaffolds in drug discovery, particularly as inhibitors or modulators in various biochemical pathways.
  • Versatile Reactions: The presence of the phenyl group on the pyrimidine ring allows for versatile synthetic transformations. It can participate in various reactions, including nucleophilic substitutions and coupling reactions, making it a valuable intermediary in organic synthesis.
  • Material Science Applications: Compounds like 4-phenylpyrimidine have applications beyond organic synthesis. They are involved in the development of advanced materials, such as organic semiconductors and OLEDs (organic light-emitting diodes), which are integral to modern electronic devices.
  • Research Studies: Numerous studies have investigated the properties of 4-phenylpyrimidine. According to one research article, "The synthesis and evaluation of pyrimidine derivatives reveal their potential in medicinal chemistry and materials science," highlighting the compound's importance across disciplines.

Given its unique structure and the broad range of applications, 4-phenylpyrimidine continues to be an area of active research, appealing to chemists and material scientists alike. Its role in drug development and advanced materials offers exciting possibilities for future discoveries.

Synonyms
4-Phenylpyrimidine
PYRIMIDINE, 4-PHENYL-
6-Phenylpyrimidine
4-phenyl-pyrimidine
VQR91IRU2R
EINECS 222-345-8
NSC 84249
BRN 0112781
CHEBI:90622
UNII-VQR91IRU2R
NSC-84249
MKLQPIYLZMLAER-UHFFFAOYSA-
DTXSID90187950
5-23-08-00009 (Beilstein Handbook Reference)
DTXCID50110441
222-345-8
inchi=1/c10h8n2/c1-2-4-9(5-3-1)10-6-7-11-8-12-10/h1-8h
mklqpiylzmlaer-uhfffaoysa-n
3438-48-0
MFCD00006111
MLS002694538
NSC84249
RW1
3b9s
4-Phenylpyrimidine, 96%
SCHEMBL2131373
CHEMBL1235765
HMS3094K17
AKOS015917050
DS-6698
SB57256
SMR001560464
SY075068
DB-048612
CS-0060519
NS00029651
EN300-130842
AC-907/25014265
Q27162633