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4-Propylpiperidine

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Identification
Molecular formula
C8H17N
CAS number
22900-09-4
IUPAC name
4-propylpiperidine
State
State

4-Propylpiperidine is in a liquid state at room temperature, making it suitable for various chemical syntheses and research applications.

Melting point (Celsius)
-57.00
Melting point (Kelvin)
216.15
Boiling point (Celsius)
158.00
Boiling point (Kelvin)
431.15
General information
Molecular weight
113.21g/mol
Molar mass
113.2060g/mol
Density
0.8491g/cm3
Appearence

4-Propylpiperidine appears as a colorless liquid. It may have a faint amine-like odor due to its chemical structure involving a piperidine ring, which is common among many nitrogen-containing heterocycles.

Comment on solubility

Solubility of 4-Propylpiperidine

4-Propylpiperidine, with its structural features arising from the presence of a propyl group attached to a piperidine ring, exhibits unique solubility properties. Understanding its solubility is crucial for applications in various fields, including pharmaceuticals and organic synthesis.

In general, the solubility of 4-propylpiperidine can be outlined as follows:

  • Polarity: The presence of a nitrogen atom within the piperidine ring contributes to its polar characteristics, while the propyl group adds a nonpolar element. This combination affects the compound's interactions with solvents.
  • Solvent Compatibility: 4-Propylpiperidine tends to be more soluble in organic solvents such as:
    • Alcohols (e.g., ethanol, methanol)
    • Aromatic compounds (e.g., toluene, xylene)
    • Chlorinated solvents (e.g., dichloromethane)
  • Water Solubility: Due to its bulky nonpolar side chain, the water solubility of 4-propylpiperidine is relatively low. However, it may exhibit limited solubility in water as a result of the polar amine group.
  • Effect of Temperature: The solubility of 4-propylpiperidine in various solvents can increase with temperature, enhancing its miscibility with organic solvents.

In summary, 4-propylpiperidine demonstrates varied solubility characteristics influenced by its molecular structure. As a compound with both polar and nonpolar attributes, it shows increased solubility in organic solvents while remaining less soluble in water. As with many organic compounds, understanding its solubility is key to predicting its behavior in chemical reactions and applications.

Interesting facts

Interesting Facts about 4-Propylpiperidine

4-Propylpiperidine is an intriguing compound that belongs to the category of piperidine derivatives. This compound is notable for several reasons:

  • Structure and Flexibility: The unique structure of 4-propylpiperidine, which consists of a six-membered ring with a propyl side chain, provides a certain level of flexibility. This makes it an interesting subject for studies related to molecular conformation and stereochemistry.
  • Biological Relevance: Compounds related to piperidine are often found in biologically active molecules. 4-Propylpiperidine has been studied for its potential effects in pharmacology, as piperidine derivatives can interact with important biological targets.
  • Flavor Chemistry: Some piperidine derivatives are known for their aromatic properties. While 4-propylpiperidine itself may not be a flavor compound, it forms a class of molecules that can be investigated for use in flavor science.
  • Research and Synthetic Relevance: Its structural characteristics make it a useful intermediate in organic synthesis. Researchers often utilize 4-propylpiperidine as a building block for the synthesis of more complex biologically active molecules.
  • Industrial Applications: Beyond academia, compounds like 4-propylpiperidine find applications in industries such as pharmaceuticals, where they could serve as precursors for the creation of new drugs.

One of the fascinating aspects of chemistry is how simple structural modifications can lead to entirely different properties and biological activities. As emphasized by renowned chemists, "The best way to predict the future is to invent it." Studying compounds like 4-propylpiperidine pushes the boundaries of knowledge and innovation in chemical science.

Synonyms
4-Propylpiperidine
PIPERIDINE, 4-PROPYL-
EINECS 244-956-9
BRN 0102935
DTXSID30176924
5-20-04-00208 (Beilstein Handbook Reference)
RefChem:100431
DTXCID8099415
244-956-9
RQGBFVLTFYRYKB-UHFFFAOYSA-N
4-n-Propylpiperidine
22398-09-0
4-(n-Propyl)piperidine
4-propyl-piperidine
MFCD00023151
Piperidine,4-propyl-
4-(prop-1-yl)piperidine
SCHEMBL26805
SCHEMBL311338
SCHEMBL357186
SCHEMBL382836
SCHEMBL771485
R5329R4DGY
SCHEMBL1691785
SCHEMBL5067390
SCHEMBL11231129
SCHEMBL27527086
STR06586
XAA39809
BBL100493
STL554287
XH1363
AKOS000305924
AT34333
PS-4076
SB41611
SY103933
DB-045899
CS-0206254
NS00027157
EN300-61263
Z963408928