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Glipizide

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Identification
Molecular formula
C21H27N5O6S
CAS number
29094-61-9
IUPAC name
4-sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide
State
State

At room temperature, Glipizide is in a solid state, appearing as a crystalline powder. It is typically stable under standard conditions of storage and handling.

Melting point (Celsius)
207.00
Melting point (Kelvin)
480.15
Boiling point (Celsius)
504.00
Boiling point (Kelvin)
777.15
General information
Molecular weight
445.55g/mol
Molar mass
445.5490g/mol
Density
1.6269g/cm3
Appearence

Glipizide is a white to off-white powder. It is practically insoluble in water and alcohols, but it is soluble in dimethylformamide. The compound usually appears in a crystalline form.

Comment on solubility

Solubility of 4-sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide (C21H27N5O6S)

The solubility of 4-sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide can be characterized by various factors, including its chemical structure and the presence of functional groups. This compound comprises multiple components that can affect its solubility in different solvents:

  • Polarity: Given the presence of sulfonamide and amine groups, which are polar in nature, the compound may exhibit better solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds through the amine and carboxylic functionalities can enhance solubility in aqueous solutions.
  • Hydrophobic Interactions: The aromatic benzamide structure may reduce solubility in non-polar solvents, likely leading to poor solubility in hydrocarbons.

In summary, while 4-sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide is expected to have moderate to good solubility in polar solvents due to its polar functional groups, its overall solubility profile will depend heavily on the solvent system employed, as well as the temperature. Experimentation is essential to determine specific solubility values.

Interesting facts

Interesting Facts about 4-Sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide

4-Sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide is a fascinating compound that belongs to the class of sulfonamide pharmaceuticals. These compounds are widely known for their ability to inhibit bacterial growth, thereby making them crucial in the development of antibiotics. Here are some intriguing aspects of this compound:

  • Mechanism of Action: Sulfonamides work by interfering with the synthesis of folic acid in bacteria, which is essential for their growth and reproduction.
  • Versatility: This compound could potentially exhibit a broad spectrum of biological activities, making it a candidate for various therapeutic applications beyond just antibacterial effects.
  • Structural Complexity: The presence of multiple functional groups, including sulfonamide and aromatic amine structures, lends to its diverse interactions with biological targets.
  • Research Potential: The compound's unique structure might offer new avenues for research in medicinal chemistry, particularly in the realm of drug design aimed at combating antibiotic resistance.

Given its structural characteristics, this compound is a perfect example of how modifications to existing drug frameworks can lead to novel therapeutic agents. Furthermore, advancing the understanding of sulfonamide derivatives like this one plays a vital role in addressing the ever-evolving challenges in health care.

As stated in a recent study, "Exploring the nuances of sulfonamide chemistry can unveil opportunities for innovative treatments in an era where antibiotic resistance poses significant threats."

Future research on 4-sulfamoyl-N-[4-(sulfanylmethylamino)butyl]benzamide could open doors to improved drug formulations and enhanced efficacy in treating infectious diseases.

Synonyms
4-sulfonamide-[4-(thiomethylaminobutane)]benzamide
4-sulfamoyl-N-{4-[(sulfanylmethyl)amino]butyl}benzamide
4-Sulfonamide-(4-(Thiomethylaminobutane))Benzamide
4-sulfamoyl-N-(4-((sulfanylmethyl)amino)butyl)benzamide
CHEMBL119084
DB04002
PD006569
NS00069473
Q27094859