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(4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

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Identification
Molecular formula
C17H21N3O4S
CAS number
61313-68-0
IUPAC name
(4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, (4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone is typically a solid. Its complex structure due to the presence of both aromatic and heterocyclic rings contributes to this solid-state characteristic.

Melting point (Celsius)
192.30
Melting point (Kelvin)
465.45
Boiling point (Celsius)
512.00
Boiling point (Kelvin)
785.15
General information
Molecular weight
364.43g/mol
Molar mass
364.4280g/mol
Density
1.3200g/cm3
Appearence

The compound (4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone typically appears as a crystalline solid with a distinctive structural arrangement due to its heterocyclic components. It is often characterized by its unique molecular structure which includes the thiazole and piperazine rings.

Comment on solubility

Solubility of (4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

The solubility of (4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone can be influenced by various factors related to its molecular structure:

  • Polarity: The presence of multiple methoxy groups and the thiazole ring can affect the overall polarity of the compound. Generally, compounds with higher polarity are more soluble in polar solvents.
  • Solvent choices: It is hypothesized that the compound may have good solubility in polar aprotic solvents such as DMSO or DMF, while exhibiting limited solubility in non-polar solvents.
  • Functional groups: The presence of the piperazine ring increases hydrogen bond donating capability, possibly enhancing solubility in aqueous environments.

In terms of practical application, understanding its solubility is essential for formulation in therapeutic settings, where:

  1. The solubility profile can dictate the bioavailability of the compound.
  2. Knowledge of its solubility can inform optimal formulation strategies for drug delivery.

In essence, while specific solubility data may be lacking, the structural attributes provide clues that can guide research on solubility characteristics to ensure effective application in various fields.

Interesting facts

Interesting Facts About (4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone

This compound, with its complex structure, serves as an excellent example of how diverse chemical synthesis can lead to novel molecules with potential applications in pharmaceuticals. Here are some intriguing aspects of this compound:

  • Biological Relevance: The presence of the thiazole ring contributes to the compound's biological activity. Thiazoles are known for their role in various bioactive compounds, making them valuable in medicinal chemistry.
  • Piperazine Derivatives: The inclusion of a piperazine moiety often enhances the pharmacological activity, including properties such as anxiolytic, antidepressant, and antipsychotic effects. This illustrates the importance of structural modifications in drug design.
  • Trimethoxyphenyl Group: The three methoxy groups on the phenyl ring amplify the compound’s lipophilicity, potentially influencing its interactability with biological membranes and its overall activity.
  • Structure-Activity Relationship (SAR): Chemists often study compounds like this to understand how variations in structure can alter their activity. This process is crucial in developing more effective drugs with fewer side effects.
  • Chemical Synthesis: The synthesis of such compounds is often a multi-step process involving several reactions, which can include condensation, coupling, and cyclization reactions. Mastering these techniques is a cornerstone of organic chemistry education.

Overall, (4-thiazol-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone is a fascinating compound that exemplifies the intricate relationship between chemical structure and biological function. As scientists continue to study such compounds, they uncover new potential therapies and deepen our understanding of chemical interactions in living systems.

Synonyms
17766-79-9
1-(2-Thiazolyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
BRN 1602266
KETONE, 4-(2-THIAZOLYL)PIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
4-(2-Thiazolyl)piperazinyl 3,4,5-trimethoxyphenyl ketone
Piperazine, 1-(2-thiazolyl)-4-(3,4,5-trimethoxybenzoyl)-
DTXSID70170365
DTXCID7092856
[4-(1,3-thiazol-2-yl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
AKOS033762554
AB00795274-01
Z211292018