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4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3Cl2F3N2
CAS number
341-58-2
IUPAC name
4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole is typically in a solid state, appearing as a stable crystalline compound.

Melting point (Celsius)
161.00
Melting point (Kelvin)
434.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
265.00g/mol
Molar mass
265.0030g/mol
Density
1.7880g/cm3
Appearence

The compound 4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole appears as a white to off-white crystalline powder. It may also be characterized by its fine crystalline structure, displaying a well-defined particle formation under magnification.

Comment on solubility

Solubility of 4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole can be influenced by several factors, including its molecular structure and interactions with solvents. This compound exhibits the following solubility characteristics:

  • Solvent Compatibility: It tends to be soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).
  • Water Solubility: Its solubility in water is relatively low, primarily due to its hydrophobic trifluoromethyl group and the presence of halogens, which contribute to its overall polarity.
  • Temperature Effects: As with many organic compounds, its solubility may increase with temperature; thus, heating the solvent prior to dissolution can be beneficial.

In summary, while 4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole shows compatibility with various organic solvents, it is less likely to dissolve readily in water—a classic trait for compounds with similar structural traits. Understanding these solubility properties is crucial for applications in fields like pharmaceuticals and agrochemicals, where formulation and delivery can be significantly affected by solubility.

Interesting facts

Interesting Facts about 4,5-Dichloro-2-(trifluoromethyl)-1H-benzimidazole

4,5-Dichloro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that showcases the intricacies of modern synthetic chemistry and pharmaceuticals. Here are some noteworthy aspects:

  • Structure and Substitution: This compound belongs to the benzimidazole family, which is well-known for its biological activity. The presence of dichloro and trifluoromethyl groups introduces unique electronic and steric properties that can significantly enhance the compound's reactivity and efficacy.
  • Biological Significance: Benzimidazole derivatives are widely studied for their pharmacological potential, particularly in the development of antiparasitic, antiviral, and anticancer agents. The specific substitutions in this compound suggest potential activity against various biological targets.
  • Industrial Applications: Beyond pharmaceuticals, compounds like this one are often utilized in agricultural chemistry as potential crop protection agents, showcasing their versatility in both health and environmental sectors.
  • Synthetic Pathways: The synthesis of such compounds often involves advanced techniques, highlighting the ingenuity in organic synthesis. The incorporation of multiple halogen substituents typically requires careful planning and execution to achieve desired selectivity.
  • Research Opportunities: As scientists continue to explore the potential of benzimidazole derivatives, this compound remains an exciting subject for research. Its unique chemical features can lead to the discovery of new compounds with enhanced biological activity.

In summary, 4,5-dichloro-2-(trifluoromethyl)-1H-benzimidazole serves as a prime example of how chemical modifications can tailor compounds for specific functions, making it a significant interest in both academic research and industrial applications. As the field of chemistry advances, the potential uses and study of such compounds provide exciting opportunities for discovery and innovation in science!

Synonyms
Chlorflurazole
Chlorflurazole [ISO]
CHLOROFLUORAZOLE
Caswell No. 327A
HSDB 2764
UNII-ZXH1IGJ511
EPA Pesticide Chemical Code 327200
BRN 0960437
Benzimidazole, 4,5-dichloro-2-(trifluoromethyl)-
CHLORFLURAZOLE [HSDB]
DTXSID0041773
DTXCID8021773
4,5Dichloro2trifluoromethylbenzimidazole
4,5Dichloro2(trifluoromethyl)benzimidazole
4,5Dichloro2(trifluoromethyl)1Hbenzimidazole
Benzimidazole, 4,5dichloro2(trifluoromethyl)
1HBenzimidazole, 4,5dichloro2(trifluoromethyl)
1-H-BENZIMIDAZOLE, 4,5-DICHLORO-2-(TRIFLUOROMETHYL)-
BENZIMIDAZOLE, 4,5(OR 6,7)-DICHLORO-2-(TRIFLUOROMETHYL)-
3615-21-2
4,5-Dichloro-2-trifluoromethylbenzimidazole
4,5-Dichloro-2-(trifluoromethyl)-1H-benzimidazole
ZXH1IGJ511
Chloroflurazole
NC 3363
4,5-Dichloro-2-(trifluoromethyl)benzimidazole
1H-Benzimidazole, 4,5-dichloro-2-(trifluoromethyl)-
4,5-Dichloro-2-(trifluoromethyl)-benzimidazole
SCHEMBL133292
KSROTSBULDYPKA-UHFFFAOYSA-N
4,5-dichloro-2-trifluoromethyl benzimidazole
Q5102926