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Forskolin

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Identification
Molecular formula
C22H34O7
CAS number
66575-29-9
IUPAC name
4,5,6-trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one
State
State

At room temperature, forskolin is a solid compound. It remains in a stable crystalline form when stored properly.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
546.20
Boiling point (Kelvin)
819.35
General information
Molecular weight
410.50g/mol
Molar mass
410.4830g/mol
Density
1.2809g/cm3
Appearence

Forskolin is a pronounced crystalline solid. The crystals are typically colorless or white, and they exhibit an appealing structure visible under a microscope.

Comment on solubility

Solubility of 4,5,6-trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one (C22H34O7)

The solubility of 4,5,6-trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one is an intriguing aspect given its complex structure. This compound contains several hydroxyl (-OH) groups, which typically enhance solubility in polar solvents. The presence of hydrophilic hydroxyl groups suggests it may be more soluble in water compared to non-polar solvents.

Key Points Regarding Solubility:

  • Polarity: Due to the multiple hydroxyl groups, the compound is likely to interact favorably with water molecules, increasing its solubility in aqueous environments.
  • Solvent Interaction: Solubility may vary significantly based on the solvent used. It could be expected to have better solubility in organic solvents like ethanol or methanol.
  • Concentration Factors: At different concentrations, the compound’s solubility might exhibit changes due to the van der Waals interactions and hydrogen bonding among molecules.
  • Temperature Influence: Generally, solubility tends to increase with temperature; thus, increased temperatures may enhance the solubility of this compound.

In summary, while the precise solubility characteristics would require empirical measurement, the inherent hydrophilicity of the hydroxyl groups strongly indicates a positive solubility profile in polar solvents. As with many compounds, solubility is influenced by various factors, including temperature, pH, and the presence of other solutes. 

Interesting facts

Interesting Facts about 4,5,6-Trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one

This compound, known for its complex structure and unique properties, belongs to a category of molecules that exhibit fascinating biological activities. Here are some intriguing facts about this compound:

  • Natural Occurrence: This compound is often found in certain natural sources, where it plays a role in plant physiology and adaptation.
  • Biological Activity: Research indicates that it may exhibit antioxidant properties, making it a subject of interest in studies related to aging and oxidative stress.
  • Structure Complexity: The tetracyclic framework of the molecule showcases an intricate arrangement of rings, which contributes to its stability and reactivity.
  • Synthetic Pathways: Chemists have explored various synthetic routes to produce this compound, highlighting its significance in organic synthesis and medicinal chemistry.
  • Potential Applications: Due to its unique functionalities, it holds promise for applications in pharmaceuticals, especially in drug discovery and development.

In addition, the compound's multiple hydroxyl groups enhance its potential for hydrogen bonding, which can influence its solubility and interaction with biological macromolecules. As a student's first encounter with such complex organic compounds, understanding this molecule can provide significant insights into the *relationship between structure and function* in organic chemistry.

As one researcher aptly noted, “The complexity of compound structures often unveils nature's elegant solutions to biological challenges.” Exploring such compounds opens up a myriad of possibilities for innovations in chemistry and medicine.

Synonyms
4,5,6-Trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyltetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one
(-)-Ingenol
Ingenol?
SCHEMBL20693649
BCP10094