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Phthalide

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Identification
Molecular formula
C8H6O2
CAS number
87-41-2
IUPAC name
4,5,6,7-tetrahydroisobenzofuran-1,3-dione
State
State

Phthalide is a solid at room temperature, usually found in its crystalline form.

Melting point (Celsius)
76.00
Melting point (Kelvin)
349.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
134.13g/mol
Molar mass
134.1330g/mol
Density
1.4195g/cm3
Appearence

Phthalide appears as a white to light yellow crystalline solid. It has a distinctive aroma, which can be described as cherry-like or reminiscent of almonds, often noticed in nature and used in flavor and fragrance applications.

Comment on solubility

Solubility of 4,5,6,7-Tetrahydroisobenzofuran-1,3-dione

When considering the solubility of 4,5,6,7-tetrahydroisobenzofuran-1,3-dione, several factors come into play that influence its behavior in various solvents. This compound's solubility is largely dictated by its molecular structure, which includes hydrophobic and polar characteristics.

Key Points on Solubility:

  • Polar Solvents: The presence of the carbonyl groups in the structure typically suggests enhanced solubility in polar solvents such as water, alcohols, and ethers. However, the complex cyclic structure may hinder complete solvation.
  • Non-Polar Solvents: Conversely, 4,5,6,7-tetrahydroisobenzofuran-1,3-dione may display better solubility in non-polar solvents, where the hydrophobic regions are favored.
  • Temperature Influence: Solubility can also vary with temperature; generally, higher temperatures increase solubility.
  • Concentration Effects: As with many compounds, at lower concentrations, solubility may not be evident until a certain threshold is reached, beyond which saturation occurs.

In summary, while 4,5,6,7-tetrahydroisobenzofuran-1,3-dione displays variable solubility depending on the solvent type and environmental conditions, its unique structure suggests a nuanced relationship with solvation. It is essential to conduct empirical tests to determine precise solubility parameters for this compound.

Interesting facts

Interesting Facts about 4,5,6,7-Tetrahydroisobenzofuran-1,3-dione

4,5,6,7-Tetrahydroisobenzofuran-1,3-dione, often denoted simply as THIBF, is a fascinating compound that draws attention for its unique structure and potential applications. Below are some compelling insights about this intriguing molecule:

  • Cyclic Structure: The compound features a bicyclic structure, which contributes to its unique reactivity and stability.
  • Biological Potential: Research suggests that derivatives of THIBF may have potential in pharmaceutical applications, particularly in the development of novel therapeutics.
  • Synthesis: The synthesis of THIBF can be achieved through various organic reactions, making it an interesting subject for synthetic chemists looking to explore complex reaction pathways.
  • Applications: Beyond pharmaceuticals, this compound may find roles in materials science, owing to its interesting electronic properties.
  • Natural Products: THIBF and its derivatives are often studied within the context of natural products, exploring their occurrence in various plant sources and their biological activities.

As a scientist or chemistry student, exploring 4,5,6,7-tetrahydroisobenzofuran-1,3-dione opens doors to discussions about organic synthesis, medicinal chemistry, and the intricate dance of electrons within cyclic compounds. The study of such molecules highlights the interplay between chemical structure and function, making chemistry not just a science, but an exciting and ever-evolving exploration of the world around us.

Synonyms
3,4,5,6-Tetrahydrophthalic anhydride
2426-02-0
1,3-Isobenzofurandione, 4,5,6,7-tetrahydro-
Cyclohexene-1,2-dicarboxylic anhydride
3,4,5,6-Tetrahydrophthalic acid anhydride
01D3M89A2W
EINECS 219-374-3
NSC 11211
NSC 61333
NSC-11211
NSC-61333
DTXSID9075298
DTXCID8037043
219-374-3
4,5,6,7-tetrahydroisobenzofuran-1,3-dione
4,5,6,7-Tetrahydro-2-benzofuran-1,3-dione
1-CYCLOHEXENE-1,2-DICARBOXYLIC ANHYDRIDE
MFCD00005917
4,5,6,7-Tetrahydro-isobenzofuran-1,3-dione
1,3,4,5,6,7-hexahydro-2-benzofuran-1,3-dione
1, 4,5,6,7-tetrahydro-
UNII-01D3M89A2W
delta-TPA
SCHEMBL40325
HMMBJOWWRLZEMI-UHFFFAOYSA-
NSC11211
NSC61333
BBL027544
STK802233
AKOS005622564
AC-3369
AS-14503
cyclohexene-1,2-dicarboxylic acid anhydride
DB-046381
C1701
NS00021913
3,4,5,6-Tetrahydrophthalic anhydride, 95%
D89450
EN300-119260
3,4,5,6-Tetrahydrophthalic anhydride, >=95%
4,5,6,7-Tetrahydro-2-benzofuran-1,3-dione #
A817177
Q27231422
InChI=1/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H2