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Phthalimide

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Identification
Molecular formula
C8H7NO2
CAS number
85-41-6
IUPAC name
4,5,6,7-tetrahydroisoindole-1,3-dione
State
State

Phthalimide is a solid at room temperature.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.15
Boiling point (Celsius)
336.40
Boiling point (Kelvin)
609.55
General information
Molecular weight
147.15g/mol
Molar mass
147.1350g/mol
Density
1.2002g/cm3
Appearence

Phthalimide appears as a white to off-white crystalline solid. It is often found in powder form and is characterized by its lack of odor.

Comment on solubility

Solubility of 4,5,6,7-Tetrahydroisoindole-1,3-dione

4,5,6,7-Tetrahydroisoindole-1,3-dione is a complex compound that exhibits variable solubility depending on the solvent in question. Generally, this compound displays the following solubility characteristics:

  • Inorganic solvents: 4,5,6,7-tetrahydroisoindole-1,3-dione tends to have low solubility in nonpolar solvents such as hexane or toluene due to its polar nature.
  • Polar solvents: The compound shows increased solubility in polar protic solvents like water and alcohols because of potential hydrogen bonding interactions.
  • Behavior in organic solvents: Moderate solubility can be observed in polar aprotic solvents like DMSO (dimethyl sulfoxide) and acetone, indicating favorable solvation dynamics due to dipole interactions.

It is important to note that factors such as temperature, pH of the solution, and the presence of other solutes can significantly impact the solubility of 4,5,6,7-tetrahydroisoindole-1,3-dione. For instance:

  • Temperature: Higher temperatures generally increase solubility for most organic compounds.
  • pH Effect: The ionization state of the compound can alter its solubility, particularly in biologically relevant environments.

In summary, the solubility of 4,5,6,7-tetrahydroisoindole-1,3-dione is influenced by its molecular structure and the nature of the solvent. When selecting a solvent for dissolution, one should consider these factors for optimal outcomes.

Interesting facts

Interesting Facts about 4,5,6,7-Tetrahydroisoindole-1,3-dione

4,5,6,7-Tetrahydroisoindole-1,3-dione is a fascinating compound that plays a significant role in several fields of chemistry and pharmacology. Here are some interesting points to consider:

  • Structural Significance: This compound features a bicyclic structure, where the isoindole ring is a key component in chemical synthesis and medicinal chemistry.
  • Biological Activities: Compounds similar to 4,5,6,7-tetrahydroisoindole-1,3-dione have shown promising potential in biological applications, including anti-inflammatory and anti-cancer properties.
  • Versatile Derivatives: The structure of this compound allows for numerous derivatives to be synthesized, leading to compounds with different functional groups and, consequently, varied biological activities.
  • Research Potential: Ongoing research is focused on its synthesis, optimization, and the exploration of its applications in drug formulation and material science.
  • Historical Context: The isoindole framework has been studied since the early 20th century, with this specific compound gaining interest due to its unique properties.

Overall, 4,5,6,7-tetrahydroisoindole-1,3-dione exemplifies the intersection of structure and function in chemical compounds, revealing how small changes in molecular design can lead to significant variations in bioactivity and utility.

As a chemistry student or researcher, delving into such compounds can provide a deeper understanding of structure-activity relationships in pharmaceutical chemistry.

Synonyms
Cis-4-cycloxexene-1,2-dicarboximide
RefChem:485679
248-667-9
27813-21-4
Tetrahydrophthalimide
3,4,5,6-Tetrahydrophthalimide
4720-86-9
4,5,6,7-Tetrahydro-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 4,5,6,7-tetrahydro-
1-Cyclohexene-1,2-dicarboximide
MFCD01735122
Phthalimide, tetrahydro-
4,5,6,7-tetrahydroisoindole-1,3-dione
CYCLOHEXENE-1,2-DICARBOXIMIDE
BRN 0136336
4R239Q5JK7
NSC-293561
5-21-10-00128 (Beilstein Handbook Reference)
EINECS 225-211-7
NSC 293561
UNII-4R239Q5JK7
Isoindole-1,3-dione, 4,5,6,7-tetrahydro-
3,4,5,6-Tetrahydro phthalimide
EINECS 248-667-9
3,5,6-Tetrahydrophthalimide
SCHEMBL171230
3,4,5,6-tetrahydrophtalimide
SCHEMBL4309011
DTXSID90963771
AC6189
NSC293561
AKOS006276532
Isoindole-1, 4,5,6,7-tetrahydro-
1H-Isoindole-1, 4,5,6,7-tetrahydro-
AS-14502
SY028917
TETRAHYDROPHTHALIMIDE, 3,4,5,6-
CS-0149740
NS00028371
720T869
3-Hydroxy-4,5,6,7-tetrahydro-1H-isoindol-1-one
4,5,6,7-Tetrahydro-1H-isoindole-1,3(2H)-dione #
Q27260384
InChI=1/C8H9NO2/c10-7-5-3-1-2-4-6(5)8(11)9-7/h1-4H2,(H,9,10,11