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4,5,7-tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H2Br3ClF3N2
CAS number
368-73-8
IUPAC name
4,5,7-tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, this compound is in a solid state, specifically as a crystalline powder. Its high molecular weight and the presence of heavy halogens like bromine and chlorine contribute to its solid state at standard conditions.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
466.31g/mol
Molar mass
466.3100g/mol
Density
2.5000g/cm3
Appearence

4,5,7-Tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole typically appears as a crystalline solid. The crystals are often a pale yellow color, although they can appear white depending on their size or purity. This appearance is characteristic of many halogenated benzimidazoles, which tend to form well-defined crystal structures.

Comment on solubility

Solubility of 4,5,7-Tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4,5,7-tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole in various solvents is influenced by its complex structure and the presence of halogen substituents. Understanding this compound's solubility can provide insights into its chemical behavior and potential applications.

Key Factors Affecting Solubility:

  • Polarity: The polarity of the compound is affected by the presence of chlorine and bromine atoms, which can create areas of varying electron density.
  • Solvent Characteristics: This compound is likely to have limited solubility in non-polar solvents due to its polar functional groups, while it may show increased solubility in polar organic solvents.
  • Hydrogen Bonding: Potential for intermolecular hydrogen bonding with polar solvents can enhance solubility.

It is important to note that the solubility might vary significantly based on temperature and the specific solvent used. In general, compounds with multiple halogen atoms may exhibit lower solubility in water due to their hydrophobic characteristics. Conversely, they could dissolve better in organic solvents like DMSO or DMF, which can accommodate their sterically bulky nature.

In summary, while 4,5,7-tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole might present challenges in solubility, exploring different solvents can yield promising results. As the saying goes, “Like dissolves like,” making it essential to consider the chemical environment when assessing solubility.

Interesting facts

Interesting Facts about 4,5,7-Tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole

The compound 4,5,7-tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating chemical that belongs to the class of benzimidazoles, a group known for their diverse biological properties. Here are some engaging insights to spark your interest:

  • Biological Activity: Compounds containing benzimidazole structures have shown a variety of biological activities, including anti-parasitic, anti-fungal, and anti-cancer properties. This particular compound's halogen substitutions may enhance its potency against certain pathogens.
  • Halogen Influence: The presence of bromine and chlorine atoms can significantly affect the compound's reactivity and stability. Such substitutions are often leveraged in drug design for creating molecules with improved therapeutic profiles.
  • Fluorinated Features: The trifluoromethyl group is a notable feature in modern medicinal chemistry due to its ability to modify the electronic characteristics of compounds. The introduction of fluorine can lead to alterations in metabolic stability and biological activity.
  • Environmental Impact: Brominated and chlorinated compounds have raised environmental concerns due to their potential role as persistent organic pollutants. Understanding the environmental fate of such compounds is crucial in assessing their risks.
  • Structural Diversity: The intricate structure of this compound showcases the vast permutations available in organic chemistry. Chemists utilize such diverse structures to develop new materials and pharmaceuticals.

In conclusion, 4,5,7-tribromo-6-chloro-2-(trifluoromethyl)-1H-benzimidazole exemplifies the intersection of chemical complexity and biological significance. As we continue to explore its properties, there is much potential for discovery in both synthetic methodologies and applications in drug development.

Synonyms
14689-60-2
BENZIMIDAZOLE, 6-CHLORO-4,5,7-TRIBROMO-2-(TRIFLUOROMETHYL)-
6-Chloro-4,5,7-tribromo-2-(trifluoromethyl)benzimidazole
DTXSID90163537
DTXCID8086028
CHZJVQDAPMZVIA-UHFFFAOYSA-N