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4,6-Dibromo-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3Br2F3N2
CAS number
51752-13-3
IUPAC name
4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole is in a solid state, usually as a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
379.90
Boiling point (Kelvin)
653.05
General information
Molecular weight
377.91g/mol
Molar mass
377.9080g/mol
Density
2.2200g/cm3
Appearence

This compound typically presents as a white to off-white crystalline solid. It forms distinct crystals that can sometimes appear slightly tinted depending on the specific synthesis methods and impurities present.

Comment on solubility

Solubility of 4,6-Dibromo-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole in various solvents can reveal much about its chemical behavior and potential applications. Generally, this compound's solubility is influenced by several factors:

  • Polarity: The presence of bromine and trifluoromethyl groups contribute to differences in polarity, affecting interactions with solvents. Typically, polar solvents will dissolve polar compounds, while nonpolar solvents will do the same for nonpolar compounds.
  • Hydrogen Bonding: Since benzimidazole compounds can engage in hydrogen bonding, their solubility might be enhanced in protic solvents that can form hydrogen bonds.
  • Temperature: As with most compounds, solubility can increase with temperature; thus, heating the solvent may help dissolve 4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole.

While specific quantitative solubility data for this compound may be limited, it is crucial to conduct experiments in various solvents to determine:

  1. The degree of solubility in common organic solvents (e.g., acetone, ethanol)
  2. Comparative solubility in polar vs. nonpolar solvents

In conclusion, evaluating the solubility of 4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole is key for its utilization in chemical reactions or formulations, highlighting the importance of solvent choice for effective applications.

Interesting facts

Interesting Facts About 4,6-Dibromo-2-(trifluoromethyl)-1H-benzimidazole

4,6-Dibromo-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound with numerous characteristics that make it a subject of interest in the field of organic chemistry. Here are some key points that highlight its significance:

  • Structural Complexity: This compound features a benzimidazole core, which is a bicyclic structure comprising a fused benzene and imidazole ring. The presence of both bromo and trifluoromethyl groups adds to the interesting reactivity and properties of the molecule.
  • Applications: Compounds like this one are of great interest in medicinal chemistry for their potential biological applications. They may be utilized in the development of pharmaceuticals, agrochemicals, and other specialized materials.
  • Fluorine in Chemistry: The trifluoromethyl group is known for imparting unique characteristics to organic molecules, such as increased lipophilicity and improved metabolic stability. This feature can enhance the bioavailability of potential drug candidates.
  • Potential in Research: Due to its electronegative elements, the compound can serve as an intriguing subject for various research studies, particularly in fields focused on drug design and development.
  • Environmental Significance: Compounds containing halogens, such as bromine and fluorine, are often studied for their environmental impact, including persistence and bioaccumulation in ecosystems. Understanding these effects becomes crucial in the formulation of new eco-friendly materials.

Overall, 4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole presents a compelling combination of structural features and potential applications that warrant further exploration in scientific research and development.

Synonyms
BENZIMIDAZOLE, 4,6-DIBROMO-2-(TRIFLUOROMETHYL)-
4,6-Dibromo-2-(trifluoromethyl)benzimidazole
6609-53-6
DTXSID40216289
DTXCID90138780
4,6-dibromo-2-(trifluoromethyl)-1H-benzo[d]imidazole
4,6-dibromo-2-(trifluoromethyl)-1H-benzimidazole
CHEMBL228258
IPVBKOUKUCKNIK-UHFFFAOYSA-N
1H-Benzimidazole, 4,6-dibromo-2-(trifluoromethyl)-