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4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H3Cl2F3N2
CAS number
51395-75-6
IUPAC name
4,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole is typically in a solid state. It is relatively stable and can be handled safely under standard laboratory conditions.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
277.00
Boiling point (Kelvin)
550.15
General information
Molecular weight
251.99g/mol
Molar mass
251.9890g/mol
Density
1.6391g/cm3
Appearence

4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole typically appears as a crystalline solid. The crystals are often colorless or white, depending on purity.

Comment on solubility

Solubility of 4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 4,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole presents interesting characteristics due to its unique chemical structure. Here are some notable aspects:

  • Polarity: The presence of both chlorinated and trifluoromethyl groups increases the compound's overall hydrophobic character, leading to lower solubility in polar solvents.
  • Solvent interaction: This compound is more soluble in non-polar solvents, such as organic solvents like dimethyl sulfoxide (DMSO) or ethanol, due to its hydrophobic nature.
  • Temperature dependence: Like many similar compounds, solubility may increase with temperature; thus, heating the solvent might enhance dissolution rates.

Quote on solubility: "Solubility can often be a gatekeeper to a compound's utility in various chemical applications." This rings particularly true for 4,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole, where understanding its solubility is crucial for its practical application in various fields.

Overall, the solubility profile of 4,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole reveals a preference for non-polar environments, necessitating careful consideration when selecting solvents for its use in laboratory or industrial contexts.

Interesting facts

Interesting Facts about 4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole

4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound in the realm of organic chemistry, particularly known for its structural complexity and potential applications. Below are some intriguing aspects of this compound:

  • Structural Features: This compound is characterized by the presence of a benzimidazole core, which is a bicyclic structure consisting of a fused benzene and imidazole ring. The presence of both chlorine and a trifluoromethyl group at specific positions highlights the *diversity of functionalization* possible within this class of compounds.
  • Biological Activities: Compounds like 4,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole have been studied for their *antimicrobial* and *antiparasitic* properties. Benzimidazoles are known to exhibit significant bioactivity, making them of interest in pharmaceutical research.
  • Fluorine's Role: The trifluoromethyl group, a common motif in drug design, can enhance *lipophilicity* and *bioavailability*. The introduction of fluorine atoms can also alter the acidity, reactivity, and overall metabolism of the compound, providing an opportunity for innovative therapeutic strategies.
  • Applications in Agriculture: Due to their efficacy, benzimidazole derivatives are utilized in agriculture as fungicides and herbicides, contributing to crop protection and yield enhancement. Such compounds are pivotal in ensuring food security.
  • Research Potential: The unique set of functional groups in this compound creates a platform for further modification and exploration. Researchers continue to investigate its potential for developing new materials, catalysts, and therapeutic agents.

In summary, 4,6-dichloro-2-(trifluoromethyl)-1H-benzimidazole exemplifies the importance of structural diversity in medicinal chemistry and agricultural sciences. The ongoing exploration of its properties can lead to the development of innovative solutions in various fields.

Synonyms
4228-88-0
BENZIMIDAZOLE, 4,6-DICHLORO-2-(TRIFLUOROMETHYL)-
4,6-Dichloro-2-(trifluoromethyl)benzimidazole
BRN 0960438
DTXSID40195106
DTXCID10117597
cafbqhrmrgnhme-uhfffaoysa-n
4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole
4,6-dichloro-2-(trifluoromethyl)-1H-1,3-benzodiazole
SCHEMBL8183601
STK765845
AKOS005080699
12M-519S
4,6-dichloro-2-trifluoromethyl-benzimidazole
AK-778/11730016
SR-01000534829
SR-01000534829-1
1H-benzimidazole, 4,6-dichloro-2-(trifluoromethyl)-
4,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazole #