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4,6-Dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H2Cl2F3N3O2
CAS number
165791-36-0
IUPAC name
4,6-dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 4,6-dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole is in a solid state. It is a stable compound under normal conditions but should be handled with care to avoid exposure to moisture, as it can be hygroscopic.

Melting point (Celsius)
248.00
Melting point (Kelvin)
521.15
Boiling point (Celsius)
395.00
Boiling point (Kelvin)
668.15
General information
Molecular weight
322.99g/mol
Molar mass
322.9920g/mol
Density
1.8900g/cm3
Appearence

4,6-Dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole is typically a solid compound. Its appearance can vary from a pale yellow to light brown crystalline powder, depending on the level of impurities present. It is generally odorless.

Comment on solubility

Solubility of 4,6-Dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

4,6-Dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole, a complex organic compound, demonstrates variable solubility based on its chemical structure and interactions with solvents. Understanding its solubility is crucial for applications in pharmaceuticals and related fields.

Solubility Characteristics

  • Solvents: This compound is generally more soluble in organic solvents such as dichloromethane and ethanol than in polar solvents like water.
  • Polarity: The presence of electron-withdrawing groups such as –Cl and –CF3 influences the electronic properties and polarity, affecting solubility.
  • Temperature: Solubility can increase with temperature, particularly in organic solvents.

In summary, the solubility of 4,6-dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole is highly dependent on the chosen solvent and temperature conditions. This highlights the importance of selecting appropriate solvents for practical applications involving this compound.

Interesting facts

Interesting Facts about 4,6-Dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole

4,6-Dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that belongs to the benzimidazole family. This class of compounds is known for its significant biological activity and utility in pharmaceuticals.

Key Features

  • Structural Importance: The compound features a benzimidazole core, which is notable for its ability to act as a scaffold in medicinal chemistry, leading to the development of various therapeutic agents.
  • Electron-Withdrawing Groups: The presence of multiple electron-withdrawing groups like chlorine and trifluoromethyl enhances the compound's reactivity and influence on biological systems.
  • Biological Activity: Compounds in this family often exhibit anti-parasitic, anti-fungal, and anti-cancer properties, making them attractive in drug discovery.

Chemical Significance

This particular compound's ability to interact with biological targets is enhanced by its diverse functional groups. The dichloro and nitro substituents can modulate the electronic properties of the aromatic system, leading to variations in pharmacological activity.

Applications in Research

In scientific research, compounds like 4,6-dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole are instrumental for:

  • Studying the mechanisms of drug action.
  • Understanding biochemical pathways for disease treatment.
  • Exploring novel synthetic routes for complex compound generation.

In summary, the intricate structure and potential applications of 4,6-dichloro-5-nitro-2-(trifluoromethyl)-1H-benzimidazole resonate strongly within the fields of chemistry and biomedicine. As researchers continue to investigate its properties, this compound serves as a prime example of how small changes in molecular structure can yield profound effects in biological interactions and therapeutic potential.

Synonyms
BENZIMIDAZOLE, 4,6-DICHLORO-5-NITRO-2-(TRIFLUOROMETHYL)-
BRN 0929434
6609-43-4
4,6-Dichloro-5-nitro-2-(trifluoromethyl)benzimidazole
DTXSID20216287
DTXCID20138778
ABRYUUSJZZOGOI-UHFFFAOYSA-N