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4,6-Dichloro-5-nitropyrimidine

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Identification
Molecular formula
C4HCl2N3O2
CAS number
1780-26-3
IUPAC name
4,6-dichloro-5-nitro-pyrimidine
State
State

At room temperature, 4,6-Dichloro-5-nitropyrimidine exists as a solid. It is stable under standard conditions and is typically manipulated as a powder in chemical processes.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
287.20
Boiling point (Kelvin)
560.35
General information
Molecular weight
192.96g/mol
Molar mass
192.9580g/mol
Density
1.6860g/cm3
Appearence

4,6-Dichloro-5-nitropyrimidine is a pale yellow crystalline powder. The compound is noted for its distinctive coloration which can aid in its identification as a solid reagent.

Comment on solubility

Solubility of 4,6-Dichloro-5-nitro-pyrimidine

4,6-Dichloro-5-nitro-pyrimidine is a compound whose solubility presents some interesting characteristics. Understanding its solubility can be crucial for various applications in research and industry. Here are some key points regarding its solubility:

  • Polarity: The presence of two chlorine atoms and one nitro group makes the molecule relatively polar, which affects its interaction with solvents.
  • Solvents: This compound tends to be soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).
  • Water Solubility: It is generally considered insoluble or only sparingly soluble in water, which limits its use in aqueous environments.
  • Temperature Effects: Like many compounds, solubility can be influenced by temperature; typically, solubility increases with rising temperature in organic solvents.

Overall, the solubility behavior of 4,6-dichloro-5-nitro-pyrimidine underscores its versatility in different chemical contexts. Its limited water solubility, combined with good solubility in polar solvents, can be harnessed for various practical applications.

Interesting facts

Interesting Facts About 4,6-Dichloro-5-nitro-pyrimidine

4,6-Dichloro-5-nitro-pyrimidine is a fascinating compound in the field of organic chemistry, particularly due to its role as a versatile building block in the synthesis of various pharmaceuticals and agrochemicals. Here are some captivating aspects of this compound:

  • Structural Significance: This compound belongs to the pyrimidine family, characterized by a six-membered aromatic ring containing nitrogen atoms. The presence of both chlorine and nitro functional groups on the ring makes it an interesting subject for studies in reactivity and substitution patterns.
  • Reactant Versatility: It is often employed in the synthesis of more complex molecules. The nitro group can serve as a precursor for reduction reactions, leading to the formation of amines, while the chlorinated positions are vulnerable to nucleophilic substitutions, facilitating further chemical transformations.
  • Biological Activity: Compounds similar to 4,6-dichloro-5-nitro-pyrimidine have shown biological relevance, particularly in medicinal chemistry where they play a role in anti-cancer and antimicrobial properties. Research continues to explore the potential therapeutic applications of such compounds.
  • Research Interest: The unique reactivity profile of this pyrimidine derivative garners interest from researchers focused on developing novel chemical methodologies, especially in the field of heterocyclic chemistry.
  • Environmental Impact: While chlorinated compounds have raised environmental concerns due to their persistence, understanding their behavior in the ecosystem is crucial for assessing risks and developing safer agrochemicals.

In summary, 4,6-dichloro-5-nitro-pyrimidine not only serves as a crucial intermediate in chemical synthesis but also presents exciting avenues for both scientific research and practical applications in various industries. As a testament to its utility, chemists are continually unraveling new facets of this compound, making it a noteworthy topic of study in contemporary chemistry.

Synonyms
4,6-Dichloro-5-nitropyrimidine
4316-93-2
4,6-Dichloro-5-nitro-pyrimidine
PYRIMIDINE, 4,6-DICHLORO-5-NITRO-
EINECS 224-340-6
NSC 89693
BRN 0162029
DTXSID9063409
4-23-00-00899 (Beilstein Handbook Reference)
DTXCID1040241
hctiszqltgayox-uhfffaoysa-n
MFCD00006107
4,6-Dichloro-5-nitro-pyridine
NSC89693
SCHEMBL304909
4,6-dichloro-5-nitroprimidine
4,6 dichloro-5-nitropyrimidine
5-nitro 4,6-dichloropyrimidine
5-nitro-4,6-dichloropyrimidine
Pyrimidine,6-dichloro-5-nitro-
SCHEMBL16593730
4, 6 dichloro-5-nitropyrimidine
4,6-dichloro-5-nitro pyrimidine
4, 6-Dichloro-5-nitropyrimidine
ALBB-023262
BCP30396
NSC-89693
STL605225
AKOS000268609
AC-2417
CS-W001986
FD09665
SB57237
4 pound not6-Dichloro-5-nitropyrimidine
BP-20087
SY001002
4,6-Dichloro-5-nitropyrimidine, >=97%
DB-009198
NS00031314
EN300-43329
SR-01000510225
SR-01000510225-1
F1371-0158
Z440610730