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4,6-Dimethyl-2(1H)-pyrimidinone

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Identification
Molecular formula
C6H8N2O
CAS number
1122-64-7
IUPAC name
4,6-dimethyl-1H-pyrimidin-2-one
State
State

At room temperature, 4,6-Dimethyl-2(1H)-pyrimidinone is in a solid state. It maintains its solid form unless subjected to temperatures above its melting point.

Melting point (Celsius)
81.00
Melting point (Kelvin)
354.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
124.15g/mol
Molar mass
124.1450g/mol
Density
1.0980g/cm3
Appearence

4,6-Dimethyl-2(1H)-pyrimidinone is a white crystalline solid, typically appearing as a powder or small crystals. It is odorless and relatively stable under normal conditions.

Comment on solubility

Solubility of 4,6-dimethyl-1H-pyrimidin-2-one

4,6-dimethyl-1H-pyrimidin-2-one exhibits interesting solubility characteristics that are worthy of discussion. This compound, classified within the pyrimidine family, demonstrates variable solubility depending on the solvent:

  • Water: This compound tends to have low solubility in water due to the presence of non-polar methyl groups that hinder interactions with polar water molecules.
  • Organic solvents: It shows a greater propensity to dissolve in organic solvents. Typical solvents include:
    • Dimethyl sulfoxide (DMSO)
    • Ethanol
    • Methanol

As a rule of thumb, the solubility of organic compounds generally increases with the increase in the number of non-polar carbon chains or methyl groups. Therefore, for 4,6-dimethyl-1H-pyrimidin-2-one, *though it is not highly soluble in polar solvents*, it finds bolstered solubility in non-polar or less polar solvent environments. This phenomenon can be summarized by the adage: "like dissolves like."

Overall, understanding the solubility profile of 4,6-dimethyl-1H-pyrimidin-2-one is crucial for its applications and interactions in various chemical processes.

Interesting facts

Interesting Facts About 4,6-Dimethyl-1H-pyrimidin-2-one

4,6-Dimethyl-1H-pyrimidin-2-one is a fascinating compound that plays a significant role in various chemical applications and research. Below are some intriguing aspects of this compound:

  • Biomedical Importance: This compound and its derivatives are studied for potential use in pharmaceuticals, particularly as anti-cancer agents and in the development of enzyme inhibitors.
  • Structure and Stability: The pyrimidinone structure provides stability due to the resonance within the ring, making it a key component for many biologically active molecules.
  • Synthetic Versatility: Chemists often explore the synthetic pathways of this compound, as it serves as a useful building block in the synthesis of more complex organic molecules.
  • Interdisciplinary Applications: Its applications extend beyond medicinal chemistry, touching fields like agrochemicals, material science, and even food chemistry where certain derivatives are explored for flavor compounds.
  • Research Significance: Ongoing research into 4,6-dimethyl-1H-pyrimidin-2-one contributes to the broader knowledge of heterocyclic compounds, which are essential in developing new drugs and materials.

As a chemistry student or scientist, the study of this compound not only enhances our understanding of organic chemistry but also opens new avenues for innovative applications in various domains. Whether exploring its synthesis or its biological activities, 4,6-dimethyl-1H-pyrimidin-2-one remains a compound of great scientific interest.

Synonyms
108-79-2
4,6-Dimethyl-2-hydroxypyrimidine
2-Hydroxy-4,6-dimethylpyrimidine
4,6-Dimethylpyrimidin-2-ol
4,6-dimethylpyrimidin-2(1H)-one
2(1H)-Pyrimidinone, 4,6-dimethyl-
4,6-dimethyl-1H-pyrimidin-2-one
4,6-Dimethyl-2-pyrimidinol
4,6-dimethyl-2(1H)-pyrimidinone
4,6-Dimethyl-2-pyrimidone
HG0CBN4V9F
MFCD00006072
EINECS 203-617-5
4,6-dimethyl-1,2-dihydro-2-pyrimidone
4,6-dimethyl-1,2-dihydropyrimidin-2-one
DTXSID5043762
4,6-dimethyl-2(1h)-pyrimidone
2-PYRIMIDINOL, 4,6-DIMETHYL-
2(1H)-PYRIMIDONE, 4,6-DIMETHYL-
4,6-Dimethyl-pyrimidin-2-ol
UNII-HG0CBN4V9F
HDP-nicarbazin
4,6-Dimethyl-2-pyrimidol
4,6-dimethylpyrimid-2-one
SCHEMBL891790
CHEMBL3706457
DTXCID3023762
2-Hydroxy-4,6-dimethylpyrimidinec
2-Hydroxy-4,6-dimethyl pyrimidine
AC7716
STK045560
STL300738
4,6-Dimethyl-2(3H)-pyrimidinone #
AKOS000117992
AKOS000121150
pyrimidine, 2-hydroxy-4,6-dimethyl-
CS-W013526
BP-10055
DS-11123
SY019688
D2427
NS00009655
EN300-27685
AC-907/25014135
AC-907/25014136
AK-830/25033020
Q27279911
Z240985804