Skip to main content

Pyrimethamine

ADVERTISEMENT
Identification
Molecular formula
C12H13N5O
CAS number
58-14-0
IUPAC name
4,7-diamino-2-phenyl-pteridine-6-carboxamide
State
State

At room temperature, pyrimethamine is in a solid state, typically as a crystalline powder.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
248.27g/mol
Molar mass
248.2680g/mol
Density
1.3630g/cm3
Appearence

Pyrimethamine appears as a white crystalline powder.

Comment on solubility

Solubility of 4,7-Diamino-2-phenyl-pteridine-6-carboxamide

The solubility of 4,7-diamino-2-phenyl-pteridine-6-carboxamide is an intriguing aspect that relates to its potential applications in various fields, particularly pharmaceuticals. This compound exhibits the following characteristics in terms of solubility:

  • Polarity: Due to the presence of amino and carboxamide functional groups, the compound is likely to have enhanced polarity, contributing to its solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of NH and CO groups to engage in hydrogen bonding can facilitate solubility, allowing for interactions with solvent molecules.
  • Solvent Dependence: While generally soluble in polar solvents, 4,7-diamino-2-phenyl-pteridine-6-carboxamide may show limited solubility in nonpolar solvents, which lack the ability to stabilize the compound.
  • pH Influence: The solubility might vary depending on the pH of the solution, as ionization can occur, especially in acidic or basic environments.

In practical terms, understanding the solubility profile of this compound is essential for optimizing its use in drug formulation and ensuring effective delivery in biological systems. As noted, "a compound's solubility can significantly influence its bioavailability and therapeutic efficacy." Therefore, further exploration of 4,7-diamino-2-phenyl-pteridine-6-carboxamide's solubility characteristics can provide valuable insights in the field of medicinal chemistry.

Interesting facts

Interesting Facts about 4,7-Diamino-2-phenyl-pteridine-6-carboxamide

4,7-Diamino-2-phenyl-pteridine-6-carboxamide is a fascinating compound that possesses a unique structure and diverse applications. This compound is part of the pteridine family, which is well-known for its role in biological processes and medicinal chemistry. Here are some noteworthy facts:

  • Biological Significance: This compound has been studied for its potential as an inhibitor of certain enzyme systems, which may have implications in cancer treatment and other diseases.
  • Synthetic Versatility: The structure of this compound allows for various synthetic modifications, enabling chemists to create derivatives that may exhibit enhanced bioactivity or improved pharmacological properties.
  • Therapeutic Potential: Compounds like 4,7-diamino-2-phenyl-pteridine-6-carboxamide are of interest in drug development due to their ability to interact with biological targets, leading to possible advancements in therapies for ailments such as infections and cancers.
  • Research Focus: Numerous studies have focused on the role of pteridine derivatives in biological systems, particularly in relation to their influence on nucleotide synthesis and the modulation of enzyme pathways.

In summary, 4,7-diamino-2-phenyl-pteridine-6-carboxamide is more than just a chemical compound; it stands at the crossroads of chemistry, biology, and medicine. Its unique properties make it a significant subject of study, inspiring researchers to explore its potential in various fields.

Synonyms
6-Pteridinecarboxamide, 4,7-diamino-2-phenyl-
NSC-265367
UNII-EMZ32S4TJC
EMZ32S4TJC
2-Phenyl-4,7-diamino-6-carboxamidopteridine
DTXSID60274543
DTXCID50226016
1230-14-4
NSC265367
2-phenyl-4,7-diamino-6-carbamoylpteridine
6-Pteridinecarboxamide,7-diamino-2-phenyl-
Q27277252