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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
State
State

At room temperature, noscapine is typically in a solid state. It is stable under normal conditions, retaining its structure as a fine crystalline powder.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
545.90
Boiling point (Kelvin)
819.10
General information
Molecular weight
413.43g/mol
Molar mass
413.4520g/mol
Density
1.3900g/cm3
Appearence

Noscapine typically appears as a white to off-white crystalline powder. It is often characterized by its finely divided form, leading to a somewhat fluffy appearance. Due to its crystalline structure, it may also display slight granularity upon close examination.

Comment on solubility

Solubility of 4a-Hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The solubility profile of the compound 4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one (C22H23NO7) is an intriguing subject in the field of chemistry. Its unique structure hints at both hydrophilic and hydrophobic characteristics, which play a significant role in its solubility behavior.

Key points regarding the solubility of this compound include:

  • Polar Functional Groups: The presence of hydroxy (–OH) and methoxy (–OCH3) groups suggests potential for hydrogen bonding, which may enhance solubility in polar solvents such as water.
  • Hydrophobic Regions: The hexahydroisoquinoline framework presents a hydrophobic character that may hinder solubility in polar environments, potentially favoring solubility in non-polar solvents.
  • pH Dependence: Solubility can be influenced by pH, as the ionization of functional groups may alter the overall polarity of the compound.
  • Solvation Effects: The surrounding solvent molecules can significantly impact solubility by stabilizing solute molecules in the solution.

In conclusion, while predicting the exact solubility of C22H23NO7 without experimental data can be challenging, its solubility is likely to depend on a delicate balance of its polar and non-polar characteristics. As chemists often say, "the solution to your solubility problem lies in understanding the structure." Therefore, practical testing and solubility assays remain essential for elucidating its true behavior in various solvents.

Interesting facts

Exploring 4a-Hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

This intriguing compound is a fascinating example of a complex molecular architecture, showcasing the rich diversity of organic chemistry. Here are some interesting facts that highlight its significance:

  • Structural Complexity: The compound features a multi-ring structure, incorporating both isoquinoline and benzofuro moieties, which contributes to its unique properties and reactivity.
  • Natural Products Connection: Compounds of similar structure often derive from natural sources, making them subjects of interest for medicinal chemistry and pharmacology due to their potential biological activities.
  • Bioactivity: While specific studies on this compound are limited, related structures are known for various activities such as anticancer, antioxidant, and antimicrobial properties.
  • Synthesis Challenges: The intricate synthesis pathway of such a compound exemplifies the challenges in organic synthesis, where chemists must navigate multiple steps and specific reaction conditions to achieve desired yields and purity.
  • Future Research Potential: With more research, this compound could reveal new pharmacological effects. As scientists continue to explore its structure-activity relationships, it may unveil novel therapeutic applications.

As one delves deeper into the world of organic compounds like 4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, the possibilities for discovery are as vast as the molecular structures themselves. This highlights the beauty of chemistry, where each compound is a potential gateway to new understanding and innovation.

Synonyms
Oxicone
Morphinan-6-one, 4,5.alpha.-epoxy-14-hydroxy-3-methoxy-17-methyl-
Tekodin (free base)
850-50-0
Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5.alpha.)-
Eucodal (Salt/Mix)
Tecodin (Salt/Mix)
Dinarkon (Salt/Mix)
col-003
4,5.alpha.-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
SCHEMBL10064505
DTXSID40859094
BRUQQQPBMZOVGD-UHFFFAOYSA-N
CGA47791
FO32141
Oxycodone-d6, 100 ug/ml methanol solution
NS00010443
L001019
4a-Hydroxy-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinolin-7(7aH)-one
4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
4aH-8,9c-Iminoethanophenanthro(4,5-bcd)furan-5(6H)-one, 7,7a,8,9-tetrahydro-7a-hydroxy-3-methoxy-12-methyl-