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Ajmalicine

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Identification
Molecular formula
C21H24N2O3
CAS number
483-04-5
IUPAC name
(4aR,5aS,8aR,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
State
State

At room temperature, Ajmalicine is generally found in a solid state.

Melting point (Celsius)
241.00
Melting point (Kelvin)
514.15
Boiling point (Celsius)
322.50
Boiling point (Kelvin)
595.70
General information
Molecular weight
352.43g/mol
Molar mass
352.4340g/mol
Density
1.2505g/cm3
Appearence

Ajmalicine typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of (4aR,5aS,8aR,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one

The solubility of complex organic compounds, such as (4aR,5aS,8aR,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one, can often present a challenge due to their intricate structures. Here are some factors influencing its solubility:

  • Molecular Structure: The stereochemical configuration and the presence of multiple functional groups, such as methoxy groups, can enhance or hinder solubility in various solvents.
  • Polarity: Compounds with polar functionalities may exhibit better solubility in polar solvents (like water or alcohols), while non-polar characteristics may favor solubility in organic solvents (like ether or hydrocarbons).
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly affect its solubility. Enhanced interactions with solvent molecules often increase solubility.

In general, the solubility of such a compound is expected to be limited in water, while it may dissolve more readily in organic solvents. Small changes in the structure, such as modifications to the methoxy groups, could lead to substantial differences in solubility properties, thus showcasing the *importance of understanding solubility for practical applications*.

As always, detailed experimental investigations are recommended to accurately determine the solubility profile of this complex molecule.

Interesting facts

Exploring (4aR,5aS,8aR,15bR)-10,11-Dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one

This fascinating compound showcases the intricate world of organic chemistry, particularly in the realm of complex nitrogen-containing heterocycles. Its structure is a stunning example of molecular architecture, where the arrangement of atoms forms a unique three-dimensional shape that can significantly influence its chemical properties and biological activity.

Key Features:

  • Multiple Functional Groups: The presence of dimethoxy groups indicates the potential for various reactions, which could be relevant in synthetic chemistry or pharmaceutical development.
  • Heterocyclic Framework: This compound is rich in heterocycles, which often play crucial roles in the biological activities of natural products and drugs.
  • Stereochemistry: The specific stereochemistry denoted by the (R, S) notation suggests that this compound may exhibit chirality, leading to interesting behavior in chirality-sensitive reactions.

From a biochemical perspective, compounds like this one can serve as precursors or lead compounds in drug design, especially in the field of antitumor and neuroprotective agents. The intricate molecular structure raises exciting possibilities for:

  1. Understanding complex biochemical interactions.
  2. Exploring new synthetic pathways in organic chemistry.
  3. Investigating pharmacokinetics and pharmacodynamics due to its unique arrangement of functional groups.

As we delve further into the chemistry of such compounds, we gain greater insight into the interplay between structure and function, enriching our understanding of both theoretical and applied chemistry. The beauty of this compound lies not just in its complexity but also in the myriad of possibilities it presents for future research and technological advancements.

Synonyms
SR-05000001553
Spectrum_001121
SpecPlus_000567
Spectrum2_000564
Spectrum3_000624
Spectrum4_001882
Spectrum5_000504
BSPBio_002188
KBioGR_002408
KBioSS_001601
DivK1c_006663
SPECTRUM1500822
SPBio_000348
SCHEMBL1648976
CHEBI:91694
KBio1_001607
KBio2_001601
KBio2_004169
KBio2_006737
KBio3_001688
HMS1921K04
HMS2092M06
Pharmakon1600-01500822
CCG-38730
NSC757797
AKOS015895960
SDCCGMLS-0066964.P001
SBI-0052330.P002
NS00003564
AB00052839_02
AB00052839_03
SR-05000001553-1
SR-05000001553-2
BRD-A41995253-001-02-9
BRD-A41995253-001-04-5
BRD-A41995253-330-01-4
BRD-A41995253-330-02-2
Q27163515
(4aR,5aS,8aR,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one