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Codeine 6-acetate

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Identification
Molecular formula
C22H25NO5
CAS number
509-67-1
IUPAC name
[(4aR,7S,12bS)-9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate
State
State

At room temperature, Codeine 6-acetate is typically in a solid state.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
371.42g/mol
Molar mass
371.4240g/mol
Density
1.3000g/cm3
Appearence

Codeine 6-acetate is typically found as a white or off-white crystalline solid. It can appear as a powder or in crystalline form, depending on its preparation and storage conditions. The compound is odorless with a bitter taste.

Comment on solubility

Solubility Characteristics

The compound [(4aR,7S,12bS)-9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate presents intriguing solubility properties that merit discussion. Understanding the solubility of such complex organic compounds can be quite challenging, but there are several useful approaches to consider:

  • Polarity: The presence of functional groups, such as acetate and acetoxy, influences the overall polarity of the molecule. This characteristic plays a crucial role in its solubility in various solvents.
  • Solvent Compatibility: It is anticipated that this compound may exhibit better solubility in polar aprotic solvents (e.g., dimethyl sulfoxide, acetone) compared to non-polar solvents (e.g., hexane).
  • Hydrogen Bonding: The ability to form hydrogen bonds, due to hydroxyl groups in the structure, can enhance solubility in polar solvents significantly.

As a general rule, one could state that:

  • Compounds with higher polarity tend to dissolve better in polar solvents.
  • Non-polar compounds are generally more soluble in non-polar solvents.
  • The presence of specific functional groups can create unique solubility profiles.

To summarize, while solubility predictions can be made based on the compound's structure and functional groups, empirical testing is often necessary to define the solubility in various environments definitively. Factors such as temperature, pH, and the solvent's nature can play crucial roles in its solubility behavior, making it a rich area for exploration!

Interesting facts

Interesting Facts about [(4aR,7S,12bS)-9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate

The compound known as [(4aR,7S,12bS)-9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate is a fascinating example of complex organic structure with various potential applications in the field of pharmaceuticals and natural product chemistry.

Chemical Characteristics

This compound has several noteworthy features:

  • Structural Complexity: Its intricate multi-ring system showcases a blend of isoquinoline and benzofuro frameworks. This complexity often correlates with unique biological activities.
  • Acetoxy Groups: The presence of acetoxy functional groups in the structure can influence its reactivity and solubility, potentially enhancing its pharmacological properties.
  • Chiral Centers: With multiple chiral centers, this compound may exhibit different pharmacological effects depending on its stereochemistry, making it a subject of interest in drug development.

Potential Applications

The structural nuances of this compound suggest several promising applications:

  • Pharmacology: Compounds of this class may exhibit various biological properties, including antitumor, anti-inflammatory, and analgesic effects.
  • Natural Product Chemistry: Isolated from certain natural sources, it reflects the rich biodiversity and potential health benefits found in nature.
  • Research Tool: Its unique structure can serve as a valuable scaffold for synthesizing analogs in medicinal chemistry, aiding in the discovery of new therapeutic agents.

Quote

As Albert Einstein once said, “The important thing is not to stop questioning.” This sentiment rings true in the world of complex organic compounds, as each structure, like our compound at hand, invites more questions about its potential and performance.

In summary, [(4aR,7S,12bS)-9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] acetate is not just a compound; it is a gateway to understanding the intricate dance of molecular structures and their real-world implications.