Interesting facts
Interesting Facts about (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
This compound is a fascinating example of a complex steroid structure, exhibiting a rich tapestry of stereochemistry and functionality. Here are some engaging aspects to consider:
- Structure Complexity: The intricate arrangement of chiral centers in this compound indicates that it is a specific stereoisomer, which can dramatically influence its biological activity and interactions in living organisms.
- Biological Relevance: Compounds like this one often play vital roles in various biological pathways. They may serve as hormones or precursors to hormones, affecting metabolism, growth, and reproduction.
- Synthesis Challenges: The synthesis of such a complex molecule is a significant challenge in organic chemistry, often requiring multi-step reactions and advanced techniques to ensure the desired stereochemistry is maintained.
- Pharmaceutical Potential: Given its structural similarity to natural steroid compounds, researchers are keenly interested in this compound for potential therapeutic applications, possibly in areas such as cancer treatment or hormone replacement therapy.
- Historical Context: The study of steroids has a long history in chemistry and medicine, tracing back to the early 20th century, when the significance of these compounds in human physiology became better understood.
In summary, the study of (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid is a prime illustration of how intricate molecular designs translate into important functions in chemistry and biomedicine. As scientists continue to unravel the complexities of such molecules, the implications for human health and industry remain substantial.
Synonyms
LITHOCHOLIC ACID
434-13-9
Lithocolic acid
Lithocholate
3alpha-Hydroxy-5beta-cholan-24-oic acid
3alpha-Hydroxy-5beta-cholanic acid
3alpha-Hydroxycholanic acid
3-alpha-Hydroxycholanic acid
5beta-Cholanic acid-3alpha-ol
NCI-C03861
3alpha-Hydroxy-5beta-cholanoic acid
CCRIS 363
(3alpha,5beta)-3-hydroxycholan-24-oic acid
3-alpha-Hydroxy-5-beta-cholanic acid
3alpha-Hydroxy-5beta-cholanate
HSDB 4113
5-beta-Cholanic acid, 3-alpha-hydroxy-
3-Hydroxycholan-24-oic acid
Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)-
5beta-Cholan-24-oic acid, 3alpha-hydroxy-
EINECS 207-099-1
3.alpha.-Hydroxycholanic acid
NSC 657956
UNII-5QU0I8393U
(3-alpha,5-beta)-3-Hydroxycholan-24-oic acid
BRN 3217757
DTXSID6020779
CHEBI:16325
17beta-(1-Methyl-3-carboxypropyl)etiocholan-3alpha-ol
5QU0I8393U
17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol
5-beta-Cholan-24-oic acid, 3-alpha-hydroxy-
MFCD00003682
NSC683770
(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Acid, Isolithocholic
NSC 683770
NSC-683770
CHEMBL1478
DTXCID80779
LITHOCHOLIC ACID [MI]
LITHOCHOLIC ACID [HSDB]
3a-hydroxy-5b-cholan-24-oate
3a-hydroxy-5b-cholan-24-oic acid
4-10-00-00785 (Beilstein Handbook Reference)
5.beta.-Cholanic acid-3.alpha.-ol
5beta-Cholan-24-oic acid-3alpha-ol
(3a,5b)-3-hydroxy-cholan-24-oate
Cholan-24-oic acid, 3-hydroxy-, (3-alpha,5-beta)-
LITHOCHOLIC ACID [EP IMPURITY]
NSC-657956
Cholan-24-oic acid, 3-hydroxy-, (3.alpha.,5.beta.)-
3.alpha.-Hydroxy-5.beta.-cholanic acid
(3a,5b)-3-hydroxy-cholan-24-oic acid
3.alpha.-Hydroxy-5.beta.-cholanoic acid
5-.beta.-Cholanic acid, 3-.alpha.-hydroxy-
3.alpha.-Hydroxy-5.beta.-cholan-24-oic acid
5.beta.-Cholan-24-oic acid, 3.alpha.-hydroxy-
Litocholic acid
URSODEOXYCHOLIC ACID IMPURITY C [EP IMPURITY]
LITHOCHOLICACID
(3beta,5beta,14beta,17alpha)-3-Hydroxycholan-24-Oic Acid
17-.beta.-(1-Methyl-3-carboxypropyl)ethiocholan-3-.alpha.-ol
3|A-Hydroxy-5|A-cholanic acid
17.BETA.-(1-METHYL-3-CARBOXYPROPYL)ETIOCHOLAN-3.ALPHA.-OL
LITHOCHOLIC ACID (EP IMPURITY)
Acid, Lithocholic
SR-05000000450
URSODEOXYCHOLIC ACID IMPURITY C (EP IMPURITY)
lithocholic-acid
NSC657956
Cholan-24-oic acid, 3-hydroxy-, (3a,5b)-
Prestwick_88
(4R)-4-((2S,5R,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo(8.7.0.02,7.011,15)heptadecan-14-yl)pentanoic acid
(4R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)pentanoic acid
(4R)-4-[(2S,5R,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanoic acid
4OA
CAS-434-13-9
5b-Cholanate-3a-ol
4q0a
ST069335
3a-Hydroxy-5b-cholanate
5b-Cholanic acid-3a-ol
Prestwick0_000796
Prestwick1_000796
Prestwick2_000796
Prestwick3_000796
Spectrum5_002021
3a-Hydroxy-5b-cholanoate
5beta-Cholanate-3alpha-ol
bmse000686
UPCMLD-DP153
3-Hydroxy-5-cholanic acid
cid_9903
Lithocholic acid, >=95%
3alpha-hydroxy Cholanic Acid
BIDD:PXR0054
SCHEMBL28449
3a-Hydroxy-5b-cholanic acid
BSPBio_000932
GTPL611
MLS002154006
3a-Hydroxy-5b-cholanoic acid
3a-Hydroxy-5ss-cholanic acid
SPBio_002871
BPBio1_001026
3alpha-Hydroxy-5beta-cholanoate
UPCMLD-DP153:001
5ss--Cholan-24-oic acid-3a-ol
HMS1570O14
HMS2097O14
HMS2269C14
HMS3714O14
HY-B0172
Tox21_201868
Tox21_302791
(3a,5b)-3-Hydroxycholan-24-Oate
3a-Hydroxy-5ss-cholan-24-oic acid
BDBM50236238
LMST04010003
s4003
AKOS016010251
CCG-220796
CS-2049
DS-3878
FL24913
ST 24:1;O3
(3a,5b)-3-Hydroxycholan-24-Oic acid
NCGC00091272-01
NCGC00091272-04
NCGC00091272-06
NCGC00091272-07
NCGC00091272-08
NCGC00256451-01
NCGC00259417-01
(4S)-4-((1S,2S,11S,5R,7R,10R,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0. 0<2,7>.0<11,15>]heptadec-14-yl)pentanoic acid
DA-75041
NCI60_028903
NCI60_030095
SMR000112168
(3alpha,5beta)-3-Hydroxycholan-24-Oate
3-ALPHAHYDROXY-5-BETA-CHOLANIC ACID
5.beta.-Cholan-24-oic acid-3.alpha.-ol
L0089
NS00031340
C03990
EN300-393802
3-ALPHAHYDROXY-5-BETA-CHOLAN-24-OIC ACID
Q3323035
SR-05000000450-2
SR-05000000450-4
SR-05000000450-5
Z2216887942
3alpha-Hydroxy-5beta-cholan-24-oic Acid (Lithocholic Acid)
Cholan-24-oic acid, 3-hydroxy-, (3-.alpha., 5-.beta.)-
Cholan-24-oic acid, 3-hydroxy-, (3-alpha,5-beta)- (9CI)
CHOLAN-24-OIC ACID, 3-HYDROXY-, (3-ALPHA,5-BETA)-(9CI)
Lithocholic acid, European Pharmacopoeia (EP) Reference Standard
AC268B61-0548-4391-90E9-546636926870
Lithocholic acid, 50 mug/mL in methanol, certified reference material
2,8-DIAMINO-9-[3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-1H-PURIN-6-ONE
(3a,5b)-3-Hydroxycholan-24-oic acid;17b-(1-Methyl-3-carboxypropyl)etiocholan-3a-ol;3-Hydroxycholan-24-oic acid
(4R)-4-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid
(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoicacid
(R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
207-099-1
Solubility of (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
The solubility of the compound (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid is influenced by various factors, mainly due to its complex structure. Here are some key considerations:
In summary, while the compound may exhibit some solubility in polar solvents, the large hydrophobic regions suggest that it will face solubility limitations in nonpolar environments. Therefore, understanding the compound's solubility profile can provide valuable insights for further applications and formulations.