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Clopidogrel

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Identification
Molecular formula
C16H16ClNO2
CAS number
120202-66-6
IUPAC name
(4R,8S,11S,12R,19S)-11,12-dichloro-19-fluoro-8-(2-fluoroacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
State
State
Clopidogrel is typically found in a solid state at room temperature. It is an active pharmaceutical ingredient used in medications.
Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
392.90
Boiling point (Kelvin)
666.05
General information
Molecular weight
321.82g/mol
Molar mass
321.8060g/mol
Density
1.3152g/cm3
Appearence
Clopidogrel is typically a white to off-white crystalline powder. It is not very soluble in water, which is characteristic of its crystalline nature.
Comment on solubility

Solubility of (4R,8S,11S,12R,19S)-11,12-dichloro-19-fluoro-8-(2-fluoroacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

The solubility of complex organic compounds such as (4R,8S,11S,12R,19S)-11,12-dichloro-19-fluoro-8-(2-fluoroacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one can vary significantly based on several factors. Understanding its solubility is crucial for applications in chemical synthesis and pharmaceutical formulations. Here are some key points regarding its solubility:

  • Polarity: The presence of chlorine and fluorine atoms in the compound suggests a degree of polarity, which can influence solubility in polar solvents like water.
  • Hydrophobicity: The complex structure and the numerous methyl groups contribute to hydrophobic characteristics that may reduce solubility in water.
  • Solvent Compatibility: This compound may be more soluble in organic solvents such as dichloromethane or ethanol rather than in polar solvents.
  • Temperature Dependency: Increased temperature could enhance the solubility of the compound in various solvents due to increased molecular motion and interactions.

In conclusion, while its solubility profile is likely complex due to its intricate structure, the compound may show limited solubility in aqueous environments but potentially greater solubility in organic solvents. Further solubility testing would provide more clarity on its behavior in different media.

Interesting facts

Interesting Facts about (4R,8S,11S,12R,19S)-11,12-dichloro-19-fluoro-8-(2-fluoroacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

This compound is a fascinating example of a complex organic molecule with diverse functionalities. Here are some interesting facts that will surely pique the interest of chemistry enthusiasts:

  • Structural Complexity: This molecule features a unique pentacyclic structure, contributing to its intricate geometry and potential biological activity. The presence of multiple rings often leads to unique properties and reactivity.
  • Chirality: The notation (4R, 8S, 11S, 12R, 19S) indicates that this molecule has several chiral centers. This chirality could lead to distinct biological activities for each isomer, making it an interesting subject of study in stereochemistry.
  • Fluorine Substituents: The inclusion of fluorine atoms is significant, as fluorine can enhance the biological activity and metabolic stability of organic compounds. Fluorinated compounds are often noted for their roles in medicinal chemistry.
  • Potential Applications: Given its complex structure, this compound could have potential applications in pharmaceuticals or agricultural chemistry. Research into similar compounds often reveals exciting properties such as antimicrobial or anticancer activities.
  • Natural Product Chemistry: This compound's intricate design might draw on principles found in nature, as many bioactive natural products showcase similarly complex scaffolds. Studying such compounds can lead to the discovery of new drugs.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound epitomizes the excitement and complexity found in the field of organic chemistry and presents vast opportunities for further research and exploration.

Synonyms
NS00124037