Skip to main content

Halichondrin B

ADVERTISEMENT
Identification
Molecular formula
C49H80Cl2O13
CAS number
110934-79-9
IUPAC name
(4R,8S,12R)-11,12-dichloro-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
State
State

Halichondrin B is a solid at room temperature, commonly used in research and developmental studies due to its complex structure and biological activity.

Melting point (Celsius)
139.00
Melting point (Kelvin)
412.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1109.32g/mol
Molar mass
1 109.3190g/mol
Density
1.2831g/cm3
Appearence

Halichondrin B is typically found as a white crystalline powder under laboratory conditions.

Comment on solubility

Solubility of (4R,8S,12R)-11,12-dichloro-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

The solubility of this compound can be intriguing due to its complex structure. Factors affecting solubility include the following:

  • Polarity: The presence of functional groups, such as the hydroxyacetyl moiety, can enhance solubility in polar solvents like water, while the larger hydrophobic segments may reduce solubility.
  • Hydrogen bonding: The ability to form hydrogen bonds due to the hydroxyl group can lead to increased solubility in alcohols and other hydrogen-bonding solvents.
  • Solvent interaction: The choice of solvent is crucial; organic solvents such as ethanol or dimethyl sulfoxide (DMSO) might better solvate this compound compared to less polar solvents.

As with many complex organic molecules, solubility may also vary with temperature: typically, increasing temperature can enhance solubility but may also lead to decomposition or alteration of compound stability.

In summary, while the solubility of (4R,8S,12R)-11,12-dichloro-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one in different solvents is quite variable and dependent on structural characteristics, one can generally expect a moderate solubility profile influenced by the specific solvent used.

Interesting facts

Interesting Facts about (4R,8S,12R)-11,12-dichloro-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

This compound, with its complex structure, belongs to a category of chemical compounds known for their remarkable variety in absorption patterns and biological activities. Here are some notable points to consider:

1. Complex Structure

  • The compound features a unique pentacyclic framework, which contributes to its intriguing chemical and physical properties.
  • Its numerous chiral centers (indicated by the R and S nomenclature) suggest that it may exhibit stereospecific behavior in biochemical interactions.

2. Biological Potential

  • This compound could have potential applications in pharmaceuticals due to its diverse functional groups, including hydroxyl and carbonyl functionalities.
  • Research has indicated that compounds with similar structures may possess antimicrobial, anti-inflammatory, and anticancer properties.

3. Synthesis Insights

  • The synthesis of this compound could serve as a valuable entry point for students and researchers interested in organic chemistry, particularly in understanding complex multi-step synthesis.
  • The presence of chlorinated substituents often enhances the reactivity of the compound, making it a focal point in various chemical reactions.

4. Environmental Impact

  • Compounds with such intricate arrangements can play a role in the study of environmental chemistry, as chlorinated compounds can persist in the environment, raising concerns about bioaccumulation.
  • Understanding their degradation pathways is crucial for assessing environmental safety.

In essence, the compound embodies a rich tapestry of chemical characteristics and potential applications, making it a fascinating subject for study in the realm of chemistry. As stated by renowned chemists, "The beauty of chemistry lies in its complexity." Exploring compounds like this can deepen our understanding of both fundamental and applied chemical sciences.