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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
(4S)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

Noscapine is a solid at room temperature. It is stable under normal conditions and does not exhibit volatility, maintaining its solid state unless subject to temperatures nearing its melting point.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
438.15
Boiling point (Kelvin)
711.30
General information
Molecular weight
413.45g/mol
Molar mass
413.4470g/mol
Density
1.3370g/cm3
Appearence

Noscapine typically appears as a white crystalline powder. It is often observed as a fine powder with a uniform appearance, denoting its purity and consistency in composition.

Comment on solubility

Solubility of (4S)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of (4S)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol can be an intriguing aspect of its chemical behavior. This compound, belonging to the class of isoquinolines, showcases its solubility characteristics due to various factors:

  • Polarity: The presence of the methoxy group may enhance the compound's polarity, potentially increasing its solubility in polar solvents.
  • Hydroxyl Group: The hydroxyl functional group (-OH) is known to bolster solubility in water due to hydrogen bonding interactions.
  • Hydrophobic Regions: Conversely, the hydrophobic portions of the molecule may impede solubility in aqueous environments.

When considering solubility, it's crucial to understand the "like dissolves like" principle. Thus, this compound may exhibit:

  • Good solubility in: Organic solvents such as ethanol and methanol.
  • Poor solubility in: Non-polar solvents, which may limit its dissolution.

In summary, the solubility of (4S)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol represents a delicate balance between polar and non-polar attributes, making it a compelling subject for further study in diverse solvent systems.

Interesting facts

Interesting Facts about (4S)-9-Methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The compound (4S)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol is a fascinating molecule with unique structural characteristics and potential applications. Here are some interesting facts about this compound:

  • Complex Structure: The intricate arrangement of its fused ring system presents a rich field for study in stereochemistry and molecular interactions.
  • Natural Product Derivative: This compound may be a derivative of natural products found in certain plants, which can lead to discussions on its biosynthetic pathways and pharmacological properties.
  • Potential Biological Activity: Many compounds with isoquinoline structures have demonstrated significant biological activities, including anti-cancer, anti-inflammatory, and neuroprotective effects.
  • Synthetic Chemistry: The synthesis of such complex compounds can involve multiple reaction steps, presenting challenges and innovations in organic synthesis techniques.
  • Chirality: The specific stereochemistry (4S) plays a critical role in how the compound interacts with biological systems, highlighting the importance of chirality in drug design and efficacy.

In conclusion, (4S)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol exemplifies the complexity and beauty of organic compounds. Understanding such molecules contributes to the broader field of medicinal chemistry and the ongoing search for new therapies.