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(−)-Tetrahydropalmatine

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Identification
Molecular formula
C21H25NO4
CAS number
2934-97-6
IUPAC name
(4S,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
State
State

The compound is typically in a solid state at room temperature and may appear as a crystalline powder. It is stable under normal conditions of storage and handling.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
476.70
Boiling point (Kelvin)
749.90
General information
Molecular weight
355.43g/mol
Molar mass
355.4140g/mol
Density
1.3080g/cm3
Appearence

The compound is generally a solid at room temperature with an appearance that is crystalline in structure. It can be found as a white to light yellow powder when synthesized for usage.

Comment on solubility

Solubility of (4S,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline

The solubility of (4S,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline is of significant interest to researchers and pharmaceuticals alike. Understanding this compound's solubility can illustrate its behavior in different environments, which is critical for various applications.

Factors Affecting Solubility

The solubility of this compound may depend on several factors:

  • Polarity: The presence of methoxy groups, which impart some polar characteristics, could enhance solubility in polar solvents.
  • Hydrophobic interactions: Given the fused ring structure, this compound might exhibit hydrophobic behavior, potentially limiting its solubility in aqueous solutions.
  • Temperature: As with many organic compounds, solubility typically increases with temperature due to increased kinetic energy.
  • pH: The pH of the environment can significantly impact the ionization and thus the solubility of the compound.

General Observations

In practical terms, it is important to note:

  • The compound is likely to have varying degrees of solubility in organic solvents versus aqueous solutions.
  • Solubility can often be benchmarked against other similar compounds to give an initial expectation of solubility behavior.
  • Experimental measures are necessary to fully characterize solubility under specific conditions.

Overall, the solubility profile of (4S,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline requires comprehensive investigation to fully understand its potential applications and limitations in various fields.

Interesting facts

Interesting Facts about (4S,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline

This intriguing compound belongs to a class of molecules that exhibit fascinating structural complexity and potential biological activities. Here are some interesting points to consider:

  • Structural Versatility: The presence of both methoxy groups and a tetrahydroisoquinoline skeleton provides this compound with a unique three-dimensional conformation, which can significantly influence its interactions with biological targets.
  • Biological Relevance: Compounds related to isoquinoline structures are often found in various natural products that exhibit a broad range of pharmacological properties, including anti-cancer, anti-inflammatory, and antimicrobial activities. This opens up avenues for potential medicinal applications.
  • Synthesis Challenges: The synthesis of such complex compounds typically involves multiple steps, requiring careful design and execution of reactions to maintain stereochemistry and achieve the desired product purity.
  • Natural Occurrence: While this particular compound may not be widely known in nature, many isoquinolines are derived from plants, contributing to their traditional medicinal uses around the world. Researchers are continually exploring new sources for these valuable compounds.
  • Research Frontier: As scientists delve deeper into the properties and effects of this compound, it could lead to the discovery of novel therapeutic agents, making it a point of interest in drug discovery research.

In conclusion, (4S,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline showcases the intricate relationship between structure and biological activity. Its synthesis, characterization, and future research could yield significant contributions to the field of medicinal chemistry.