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Doxycycline

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Identification
Molecular formula
C22H24ClN2O8
CAS number
564-25-0
IUPAC name
(4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
State
State

At room temperature, doxycycline is typically found in a solid state as a light yellow crystalline powder.

Melting point (Celsius)
201.00
Melting point (Kelvin)
474.15
Boiling point (Celsius)
960.00
Boiling point (Kelvin)
1 233.15
General information
Molecular weight
444.44g/mol
Molar mass
444.4350g/mol
Density
1.5400g/cm3
Appearence

Doxycycline typically appears as a yellow powder. It can be found in the form of solid crystals and is sensitive to light, which can lead to degradation.

Comment on solubility

Solubility of (4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

The solubility of complex organic compounds like (4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione can be highly variable and is influenced by several factors:

  • Polarity: The presence of functional groups such as amino and hydroxy groups can contribute to the polar character of the compound, potentially enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl groups can form hydrogen bonds with solvent molecules, which usually increases solubility.
  • Size and Structure: The bulky groups in the compound's structure may hinder solubility in certain solvents. Larger structures can also lead to decreased interaction with solvent molecules.
  • pH Dependence: The solubility may vary with the pH of the solution, especially for compounds with amine groups that can be protonated or deprotonated.

In conclusion, while a detailed experimental solubility assessment for this particular compound is paramount, it can be anticipated that interaction with various solvents and alteration of conditions (like temperature and pH) will play a significant role in determining its overall solubility. Understanding these factors can help predict and optimize solubility in practical applications.

Interesting facts

Interesting Facts about (4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

This compound belongs to the class of molecules that exhibit fascinating structural characteristics and biological activities. Its complex structure is indicative of a rich chemistry that can unfold in various applications. Here are some intriguing aspects:

  • Chirality and Asymmetry: The intricate stereochemistry, reflected in its multiple stereocenters, contributes significantly to its potential biological properties. Compounds with chiral centers often show different pharmacological effects, making stereochemistry a critical area of study in drug development.
  • Biologically Active: Many derivatives of compounds similar to this one have exhibited notable biological activities, including antimicrobial and anticancer properties. Studying the biological interactions of this compound can lead to insights into potential therapeutic uses.
  • Versatile Functional Groups: The presence of various functional groups such as amino, hydroxyl, and chloro enhance the compound's reactivity and interaction with biological systems. These groups can play pivotal roles in mediating biochemical pathways.
  • Potential in Organic Synthesis: The multi-functional nature of this compound illustrates its value in organic synthesis. Researchers might explore using it as a building block in the creation of more complex molecules.
  • Environmental Impact: Understanding the behavior and breakdown of such compounds in the environment can aid in the assessment of their ecological risks and benefits.

Quote from a renowned chemist: “The beauty of chemistry lies not just in the compounds themselves, but in the stories they tell and the transformations they undergo.” This compound embodies that sentiment, opening doors to countless possibilities in chemical research and application.

Overall, the examination of ((4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione) is not only a journey into its structural intricacies but also an exploration of its potential impact in various fields of science.