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Galantamine

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Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
(4S,4aR,7aR,12bS)-9-hydroxy-3,7a-dimethyl-2,4,4a,5,6,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
State
State

At room temperature, galantamine typically exists as a crystalline solid, often prepared as its hydrobromide salt for pharmaceutical use.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
457.15
Boiling point (Kelvin)
730.30
General information
Molecular weight
287.36g/mol
Molar mass
287.3560g/mol
Density
1.3123g/cm3
Appearence

Galantamine is a white to off-white crystalline powder. It is often found in the form of a hydrobromide salt to enhance its solubility and stability.

Comment on solubility

Solubility of (4S,4aR,7aR,12bS)-9-hydroxy-3,7a-dimethyl-2,4,4a,5,6,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The solubility of complex organic compounds such as (4S,4aR,7aR,12bS)-9-hydroxy-3,7a-dimethyl-2,4,4a,5,6,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one can be influenced by a variety of factors. Understanding its solubility characteristics is crucial for its application in medicinal chemistry and materials science.

Factors Affecting Solubility:

  • Molecular Structure: The presence of hydroxyl groups can increase solubility in polar solvents.
  • Polarity: Compounds with polar functional groups tend to dissolve more readily in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can promote solubility in biological systems.
  • Temperature: Generally, higher temperatures lead to increased solubility.

It's worth noting that certain organic compounds, though highly structured and potentially crystalline, may exhibit limited solubility in common solvents, particularly if they are more non-polar in nature. As a result, conducting solubility tests across various solvents is essential. Researchers often observe that:

  • Some compounds may be insoluble in water but soluble in organic solvents.
  • Aqueous solubility can vary greatly depending on the pH of the solution.

In summary, the solubility of (4S,4aR,7aR,12bS)-9-hydroxy-3,7a-dimethyl-2,4,4a,5,6,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one necessitates a meticulous consideration of its molecular geometry and the solvents in which it is being tested. This complexity emphasizes the importance of thorough analysis in scientific research.

Interesting facts

Interesting Facts about (4S,4aR,7aR,12bS)-9-hydroxy-3,7a-dimethyl-2,4,4a,5,6,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

This complex compound belongs to a fascinating class of molecules known as natural products. These compounds often exhibit a rich array of biological activities, leading to their potential use in various therapeutic applications. Here are some intriguing facts about this compound:

  • A unique structure: The intricate arrangement of carbon and heteroatoms in this compound contributes to its unique chemical properties and reactivity.
  • Role in medicine: Natural products like this one are extensively studied for their pharmacological properties, often serving as lead compounds in drug development.
  • Source of inspiration: This compound's complexity exemplifies the vast potential of nature to inspire synthetic chemists to create novel compounds with desirable properties.
  • Biochemical pathways: Understanding how such compounds interact with biological systems is a pivotal area of research, shedding light on fundamental metabolic processes.

As one delves into the structure-function relationship of this compound, it becomes evident that each element plays a crucial role in its activity. Scientists often quote, "Nature is the best chemist," reflecting how these natural compounds can lead to groundbreaking discoveries in chemistry and medicine. The investigation of compounds like this one is not merely an academic pursuit; it holds the potential for real-world applications in treating various diseases.

In summary, the intricate details and biological significance of (4S,4aR,7aR,12bS)-9-hydroxy-3,7a-dimethyl-2,4,4a,5,6,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one make it a subject of great interest in both the scientific community and potential pharmaceutical developments.