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Galanthamine hydrochloride

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Identification
Molecular formula
C17H21NO3·HCl·H2O
CAS number
1953-04-4
IUPAC name
(4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrate;hydrochloride
State
State

Under standard conditions, galanthamine hydrochloride is in a solid state, featuring a crystalline structure that is characteristic of many pharmaceutically active compounds.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
368.89g/mol
Molar mass
368.8860g/mol
Density
1.3200g/cm3
Appearence

Galanthamine hydrochloride typically appears as a white to off-white crystalline powder. It is known for its purity and crystalline nature, which allows it to be easily handled and measured for scientific and pharmaceutical purposes.

Comment on solubility

Solubility Characteristics

The compound (4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrate;hydrochloride exhibits intriguing solubility properties, which can be influenced by several factors.

Factors Influencing Solubility:

  • Hydration: The presence of water molecules in the hydrate form often enhances solubility in aqueous solutions.
  • Salt Form: As a hydrochloride, the ionic nature can increase solubility in polar solvents compared to its uncharged form.
  • Polarity: The methoxy and methyl groups may impart some degree of hydrophobicity, influencing interaction with different solvents.

In general, one might observe that:

  1. Chenical compounds with similar structural motifs tend to show higher solubility in organic solvents.
  2. The hydrochloride form may dissolve readily in water, making it more bioavailable in pharmaceutical applications.

In summary, understanding the solubility of this compound is crucial, as it plays a significant role in pharmaceutical formulation and efficacy. Emphasizing the interplay of hydration, ionic character, and molecular structure is key to predicting its behavior in various mediums. As noted, *"Solubility is an essential parameter that determines the fate of a compound in biological systems."*

Interesting facts

Interesting Facts about (4S,4aR,7aR,12bS)-9-Methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrate;hydrochloride

This intriguing compound, belonging to the class of isoquinoline derivatives, offers a wealth of scientific interest due to its unique structure and potential biological activities. Here are some engaging insights:

  • Structural Complexity: The compound showcases a remarkable multi-ring structure that is characteristic of many natural products, suggesting intricate biosynthetic pathways.
  • Biological Significance: Research has indicated that isoquinoline derivatives often possess notable pharmacological properties. They can exhibit pharmacological effects such as antitumor, antimicrobial, and anti-inflammatory activities.
  • Hydrochloride Form: The hydrochloride salt form of this compound enhances its solubility, thereby facilitating its use in various applications, particularly in therapeutic settings.
  • Stereochemistry: The specific stereochemistry represented by the various stereocenters (S and R configurations) in the molecular structure underscores the importance of chirality in biological activity, influencing how the compound interacts with biological systems.
  • Natural Origins: Similar compounds are often found in nature, frequently derived from plants, opening avenues for exploration in herbal medicine and natural product chemistry.
  • Research Applications: Given its structural features, this compound could serve as a lead structure in drug design, prompting further studies to elucidate its mechanism of action and explore its therapeutic potential.

In conclusion, the fascinating chemistry of (4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrate;hydrochloride exemplifies the intersection of structural elegance and biological relevance, making it a worthy subject of study in the field of medicinal chemistry.