Galanthamine | Solubility of Things

Identification

Molecular formula

C₁₇H₂₁NO₃

CAS number

357-70-0

IUPAC name

(4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

State

At room temperature, Galanthamine is a solid.

Melting point (Celsius)

125.00

Melting point (Kelvin)

398.15

Boiling point (Celsius)

342.00

Boiling point (Kelvin)

615.15

General information

Molecular weight

287.35g/mol

Molar mass

287.3520g/mol

Density

1.3325g/cm³

Appearence

Galanthamine appears as a white or almost white crystalline powder. It is soluble in chloroform, sparingly soluble in ethanol and practically insoluble in water.
It is optically active and has a faint odor.

Comment on solubility

Solubility Characteristics of (4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The solubility of the compound (4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one is influenced by several factors, including its molecular structure and the presence of functional groups. Understanding its solubility profile is vital for its application in various fields.

Factors Affecting Solubility

Several key factors determine the solubility of this complex compound:

Molecular Weight: Higher molecular weights often correlate with lower solubility in solvents due to increased size and intermolecular forces.
Polarity: The presence of the methoxy group may increase solubility in polar solvents, while other structural features may favor solubility in non-polar solvents.
Hydrophilicity vs. Hydrophobicity: The balance of hydrophilic and hydrophobic components in the structure will dictate how well the compound dissolves in different solvent environments.

Expected Solubility

Although exact solubility values may require empirical testing, one can make general predictions:

If the compound is relatively polar, it may show good solubility in water and other polar solvents.
In contrast, if hydrophobic characteristics dominate, low solubility in water but higher solubility in organic solvents like ethanol or chloroform may be observed.

In conclusion, the solubility of (4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one presents a complex interplay of factors that merits further investigation for precise assessment and utility in chemical applications.

Interesting facts

Exploring a Unique Chemical Compound

The compound known as (4S,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one presents a fascinating study in organic chemistry. Its complex structure is indicative of intricate molecular interactions, making it a subject of interest for many researchers. Here are some intriguing aspects of this compound:

Stereochemistry: The compound features several stereocenters, contributing to its chiral properties. This chirality can significantly influence its biological activities and interactions with other molecules.
Structural Uniqueness: The presence of a methanobenzofuro system uniquely positions this compound within a class of natural products, which often exhibit various pharmacological roles.
Applications in Medicine: Compounds with similar structures have been investigated for their potential therapeutic effects. Studies suggest that its derivatives may have roles as anticancer or neuroprotective agents, providing exciting avenues for further research.
Natural Occurrence: Structures akin to this compound are often found in plants, suggesting that it may play significant roles in ecological interactions, perhaps acting as a defense mechanism against herbivores.

As a visually captivating and chemically complex molecule, this compound not only challenges our understanding but also highlights the vast potential of organic compounds in medicinal chemistry. One can only wonder what further insights will be uncovered through ongoing research!