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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
(4S,4aR,7R,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

Noscapine is found in a solid state at room temperature.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
346.30
Boiling point (Kelvin)
619.45
General information
Molecular weight
413.47g/mol
Molar mass
413.4710g/mol
Density
1.3280g/cm3
Appearence

Noscapine appears as a white crystalline powder. It is odorless and has a bitter taste. When exposed to air or light, it may slowly degrade.

Comment on solubility

Solubility of (4S,4aR,7R,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of the complex compound, (4S,4aR,7R,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, can be affected by various factors:

  • Polarity: The presence of methoxy groups and hydroxyl groups typically enhances solubility in polar solvents like water.
  • Hydrophobic regions: Areas of hydrophobicity in the molecular structure may lead to lower solubility in aqueous environments, creating a complex balance.
  • Interaction with solvents: The nature of the solvent can significantly impact solubility, with polar solvents generally facilitating better solubility of polar compounds.

Researchers often note the following when discussing solubility:

  1. “Solubility is influenced by temperature; higher temperatures can enhance solubility for many organic compounds.”
  2. “pH can also affect the solubility of compounds containing acidic or basic functional groups.”

Overall, understanding the solubility characteristics is pivotal for applications in pharmacology and organic chemistry, where the solubility profiles dictate usage and functionality of the compound in various environments. To summarize:

  • High solubility in organic solvents likely.
  • Potentially limited solubility in water due to hydrophobic components.
  • Further studies are essential to quantify exact solubility parameters.
Interesting facts

Interesting Facts About (4S,4aR,7R,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This compound, belonging to the class of methanobenzofuroisoquinolines, represents a fascinating area of study due to its unique structural characteristics and potential biological activities. Here are some captivating insights:

  • Synthesis and Structural Complexity: The compound showcases a complex fused ring system that is challenging to synthesize. Its stereochemistry contributes significantly to its reactivity and interaction with biological systems.
  • Biological Significance: Many compounds with similar structures have been researched for their potential medicinal properties. Preliminary studies suggest that they may exhibit neuroprotective effects, making them of interest in the field of pharmacology.
  • Natural Occurrence: Compounds analogous to this one are often found in various plant species. Their natural occurrence points to the importance of these compounds in ecological interactions and potential uses in traditional medicine.
  • Analytical Techniques: Analyzing such complex molecules often requires advanced techniques such as NMR spectroscopy, mass spectrometry, and chromatography to fully understand their properties.
  • Research Potential: As scientists continue to explore the varying applications of this compound, there is ongoing research into its ability to modulate biological pathways, which could lead to new therapeutic agents.

In summary, the intriguing structure and potential application of (4S,4aR,7R,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol open many avenues for exploration in both chemistry and biology. As we delve deeper into the world of such compounds, the possibilities for new discoveries are boundless!