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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
(4S,4aR,7S,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

State at Room Temperature: Noscapine is a solid under standard conditions.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
395.15
Boiling point (Kelvin)
668.30
General information
Molecular weight
413.44g/mol
Molar mass
413.4520g/mol
Density
1.3500g/cm3
Appearence

Noscapine appears as a white, crystalline powder. It is odorless and slightly bitter in taste. It may also be found in a colorless to white crystalline form, depending on its purified state.

Comment on solubility

Solubility of (4S,4aR,7S,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of the compound (4S,4aR,7S,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol is an intriguing aspect that can greatly influence its applications and effectiveness. Here are some key points related to its solubility:

  • Polarity: The presence of the methoxy group contributes to polarity, which can enhance solubility in polar solvents.
  • Hydrophobic Regions: The hexahydroisoquinoline structure likely includes hydrophobic characteristics, which may lead to reduced solubility in water.
  • Solvent Compatibility: This compound can potentially be more soluble in organic solvents such as ethanol, methanol, or dichloromethane.
  • pH Influence: The solubility may also be affected by the pH of the solution, as ionizable groups can increase solubility in certain conditions.
  • Temperature Dependency: Typically, increasing the temperature can improve solubility, thereby facilitating better dissolution in the desired medium.

In summary, the solubility of this compound is influenced by its structural features, the nature of the solvent, and environmental conditions. As stated in various studies, understanding these factors is critical for optimizing the use and formulation of such complex compounds in scientific and medicinal applications.

Interesting facts

Interesting Facts about (4S,4aR,7S,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This complex organic compound, commonly recognized for its intricate structure, belongs to a class of molecules known for their diverse biological activities. Here are some engaging facts:

  • Structural Complexity: The compound exhibits a rich polycyclic framework that contributes to its unique properties and reactivity, making it a subject of interest in organic chemistry.
  • Natural Sources: Compounds similar to this one are often derived from natural products, which may offer pharmaceutical potential. Many molecules in this class have been linked to biological activities such as anti-inflammatory, anticancer, and antimalarial effects.
  • Stereochemistry: The specified stereochemical configuration (4S, 4aR, 7S, 12bS) highlights the importance of stereochemistry in influencing the biological activity and interaction of the compound with biological targets.
  • Research Potential: Given the compound's structure, researchers are investigating its derivatives for potential medicinal applications. This includes studying the mechanism through which the compound exerts its biological effects.
  • Mechanistic Studies: Studying compounds with such complex structures can be challenging but rewarding, as it often leads to discoveries of new reaction pathways and mechanisms, enhancing our understanding of organic synthesis.

As a chemistry student, delving into the study of this compound opens up fascinating discussions about the intersection of structure and function in organic molecules. As the famous chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." In the case of (4S,4aR,7S,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol, exploring its properties could inspire new ideas in medicinal chemistry and beyond.