Galanthamine | Solubility of Things

Identification

Molecular formula

C₁₇H₂₁NO₃

CAS number

357-70-0

IUPAC name

(4S,4aR,7S,7aR,12bS)-3-allyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

State

At room temperature, galanthamine is in the form of a solid. It is typically distributed as a crystalline powder for various applications in pharmacology, particularly for the treatment of cognitive decline in Alzheimer's disease.

Melting point (Celsius)

126.00

Melting point (Kelvin)

399.15

Boiling point (Celsius)

376.80

Boiling point (Kelvin)

649.95

General information

Molecular weight

287.36g/mol

Molar mass

287.3500g/mol

Density

1.3500g/cm³

Appearence

Galanthamine appears as white, crystalline powder. It is odorless and has a bitter taste. The crystals are typically well-formed and fine, giving it a smooth texture. It is hygroscopic, which means it can absorb moisture from the air.

Comment on solubility

Solubility of (4S,4aR,7S,7aR,12bS)-3-allyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

The solubility of the compound C₁₇H₂₁NO₃ can be influence by several factors, making it an intriguing subject for exploration. Generally, the solubility of organic compounds like this one can vary widely based on their functional groups, molecular structure, and environmental conditions. Below are key aspects to consider:

Polarity: Due to the presence of hydroxyl (-OH) groups, this compound exhibits some level of polarity, potentially enhancing its solubility in polar solvents such as water or alcohols.
Hydrogen Bonding: The -OH groups can engage in hydrogen bonding, which can facilitate solvation in polar environments.
Hydrophobic Characteristics: The hydrocarbon portion of the molecule may impart hydrophobic attributes, making the compound less soluble in highly polar solvents but more in organic solvents such as chloroform or ether.
Temperature Dependence: Solubility often increases with temperature; thus, heating the solvent may improve the dissolution of this compound.

In summary, the solubility of C₁₇H₂₁NO₃ is likely to be moderate in polar solvents due to its functional groups but may also show variability depending on the solvent chosen and the environmental conditions present. Understanding the solubility behavior of such a complex structure can yield insights into its potential applications in various scientific fields.

Interesting facts

Interesting Facts about (4S,4aR,7S,7aR,12bS)-3-allyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

This fascinating compound belongs to a class of chemical compounds that exhibit a unique structural arrangement, often leading to interesting biological and chemical properties. Here are some key points that highlight its significance:

Complex Structure: The nomenclature of this compound reveals its complex multi-cyclic structure, which is characteristic of many natural products. This complexity is a prime area of interest in organic chemistry.
Potential Biological Activity: Compounds with similar structures often showcase various biological activities, such as anti-inflammatory and neuroprotective effects. This raises questions about its potential therapeutic applications.
Natural Sources: While this compound might be synthesized in a laboratory, many related compounds are derived from natural sources, particularly in the realm of alkaloids and terpenes. Studying its natural counterparts can provide insights into its synthesis.
Stereochemistry: With specific stereochemical configurations, it exemplifies the importance of chirality in drug design, where the orientation of atoms can significantly influence a compound's behavior in biological systems.
Research Opportunities: Its unique properties make it a noteworthy subject for research in pharmacognosy and medicinal chemistry, where scientists explore natural compounds for potential drug developments.

In summary, this compound offers a rich field of study for chemists and biologists alike. Its unique characteristics challenge researchers to explore new avenues in synthesis and application, highlighting the intricate dance between structure and function in the world of chemistry.

As noted in the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound could inspire numerous ideas and innovations in scientific research!