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Galanthamine

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Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
(4S,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
State
State
The compound is a solid at room temperature, appearing as a crystalline powder.
Melting point (Celsius)
126.50
Melting point (Kelvin)
399.65
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.00
General information
Molecular weight
287.35g/mol
Molar mass
287.3450g/mol
Density
1.3000g/cm3
Appearence
Galanthamine appears as a white crystalline powder, which is practically insoluble in water. It is often found in a processed form for various applications, mainly pharmaceuticals.
Comment on solubility

Solubility Analysis of (4S,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

The solubility of complex organic compounds like (4S,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol can fluctuate based on various factors, including molecular structure and polarity. While the specific solubility characteristics may not be extensively documented, some general insights can be highlighted:

  • Polarity: Compounds with multiple hydroxyl groups, like this one, typically exhibit increased solubility in polar solvents due to hydrogen bonding.
  • Organic Solvents: The presence of significant aliphatic and cyclic structures may enhance solubility in organic solvents such as ethanol or methanol.
  • Water Solubility: Conversely, high molecular weight or heavily substituted structures could limit solubility in water, leading to possible precipitation.

As stated by solubility theory, "like dissolves like," indicating that the solvent's polarity should match that of the solute for optimal dissolution. It is beneficial to conduct experimental studies to ascertain the precise solubility in various solvents, which may reveal the compound’s potential applications or formulations.

Therefore, while quantitative solubility data may require further investigation, the outlined factors provide a foundational understanding of solubility behavior for this intricate compound.

Interesting facts

Interesting Facts about (4S,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

This fascinating chemical compound, recognized for its complex structure, belongs to a group of naturally occurring alkaloids. Here are some intriguing aspects of this compound:

  • Unique Structure: The compound features a multifaceted ring system that contributes to its distinct properties. The presence of multiple stereocenters signifies its potential for stereoisomerism, which affects its biological activity.
  • Biological Significance: Compounds of this class have garnered interest due to their potential pharmacological properties. Many related alkaloids are noted for their medicinal effects, such as antitumor, analgesic, and anti-inflammatory activities.
  • Natural Occurrence: This structure may be synthesized in nature through biosynthetic pathways involving various enzymes, thus highlighting the complexity of natural product chemistry.
  • Potential Applications: Researchers are exploring this compound's reactivity and potential applications in drug design. Its unique framework provides a scaffold for synthesizing novel therapeutic agents.
  • Research Challenges: Due to the intricacies of synthesizing such compounds, chemists often face challenges in achieving high yields and purities, making it a topic of ongoing research and innovation in synthetic organic chemistry.

In the words of famous chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” This emphasizes the continuous exploration and innovation in the field of chemistry, making compounds like this a vital part of scientific discovery.


As we delve deeper into the study of such complex structures, we can uncover not only the mysteries of chemical interactions but also the remarkable potential they hold for human health and technology.