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Tylophorine

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Identification
Molecular formula
C24H27NO3
CAS number
482-26-0
IUPAC name
(4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

At room temperature, Tylophorine is typically found in a solid state. Additionally, it is characterized by its crystalline form and may appear slightly yellow depending on purity and specific formulation.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
326.00
Boiling point (Kelvin)
599.15
General information
Molecular weight
381.48g/mol
Molar mass
381.4510g/mol
Density
1.3500g/cm3
Appearence

Tylophorine appears as a crystalline solid that can vary in color from white to pale yellow. It typically forms as fine crystals, and when observed under a microscope, the crystalline nature is evident with well-defined edges and surfaces.

Comment on solubility

Solubility of (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of complex organic compounds such as (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol is influenced by several factors:

  • Polarity: The presence of functional groups can determine whether a compound is more soluble in polar or nonpolar solvents. In this case, the methoxy group may increase solubility in polar environments.
  • Hydrogen Bonding: The hydroxyl (–OH) group can engage in hydrogen bonding, potentially enhancing solubility in water.
  • Molecular Weight: Higher molecular weight compounds may exhibit lower solubility, particularly in certain solvents, due to reduced mobility.
  • Temperature: Typically, solubility increases with temperature. Therefore, the solubility of this compound may vary significantly with changes in temperature.

To summarize, the solubility of (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol is likely to be affected by its unique structural features and the conditions in which it is analyzed. Understanding solubility is crucial for practical applications, including formulation in pharmaceuticals, where the compound's bioavailability is often a key factor in efficacy.

Interesting facts

Interesting Facts about (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This compound, though complex, presents fascinating characteristics that intrigue both chemists and biochemists alike. Here are some remarkable aspects:

  • Structural Complexity: The compound features a multi-ring structure that contributes to its unique properties. The presence of multiple stereocenters emphasizes the intricacies involved in its synthesis and behavior.
  • Natural Occurrence: Compounds similar to this one are often found in various plant species, particularly those utilized in traditional medicine, hinting at potential therapeutic applications.
  • Biological Interest: Researchers are exploring the compound's potential bioactivity, with studies indicating that derivatives of isoquinoline structures can exhibit significant pharmacological properties, such as analgesic and anti-inflammatory effects.
  • Synthetic Challenges: The synthesis of this compound may pose challenges due to its stereochemistry and the presence of multiple functional groups, making it a fascinating subject for organic synthesis enthusiasts.
  • Potential Applications: With ongoing research, there are prospects for use in drug design and development, as well as in the formulation of natural products due to its complex structure and potential activity.

In essence, the study of this compound not only broadens our understanding of organic chemistry but also paves the way for innovations in medicinal chemistry and sustainable pharmaceuticals. As one researcher elegantly stated, *"The beauty of chemistry lies in the complexity of its compounds and the endless possibilities they hold for advancements in science."*