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Codeine phosphate

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Identification
Molecular formula
C18H24NO7P
CAS number
52-28-0
IUPAC name
(4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol;phosphoric acid
State
State

At room temperature, codeine phosphate is typically in a solid state. It is stored in this form for medicinal use and can be dissolved for certain applications.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
406.38g/mol
Molar mass
406.3750g/mol
Density
1.3400g/cm3
Appearence

Codeine phosphate appears as a white or slightly off-white crystalline powder. It is highly soluble in water, which is characteristic of many phosphate salts. The compound may also be available in granulated forms for pharmaceutical use.

Comment on solubility

Solubility of (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol;phosphoric acid

The solubility of the compound C18H24NO7P can be influenced by several factors. Understanding these will aid in its practical applications:

  • Polarity: The presence of functional groups, such as the methoxy and phosphoric acid moieties, typically enhances polarity, making the compound more soluble in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl group (–OH) in the phosphoric acid may facilitate hydrogen bonding with water molecules, contributing to increased solubility.
  • Solvent Compatibility: The solubility behavior can vary notably. For instance:
    • In Water: Increased solubility due to polar interactions.
    • In Organic Solvents: Solubility may decline as the molecule's hydrophobic character emerges.
  • Temperature: Generally, higher temperatures can improve solubility, allowing more of the compound to dissolve in a given solvent.

In summary, the solubility of this compound is likely to be significantly influenced by its chemical structure, with a tendency towards improved solubility in polar solvents due to both polarity and hydrogen bonding capabilities. Experimentation in various solvents at different temperatures would provide a comprehensive understanding of its solubility profile.

Interesting facts

Interesting Facts about (4S,4aR,7S,7aR,12bS)-9-Methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol; Phosphoric Acid

This complex compound represents a fascinating intersection of organic chemistry and medicinal applications. Characterized by its intricate structure, this molecule is a member of the broader isoquinoline family—a group known for its significant biological activity. Here are some intriguing points to consider:

  • The compound features multiple stereocenters, which ultimately contributes to its potential chiral properties. Chirality plays a key role in drug interactions, affecting how a compound behaves in biological systems.
  • Its structural components include a methoxy group, which can enhance the lipophilicity of the compound, making it more permeable to biological membranes. This property can be crucial for drug delivery and absorption.
  • Phosphoric acid, included in this compound, often acts as a catalyst in organic reactions and serves various functions in biochemistry, such as energy transfer in the form of ATP (adenosine triphosphate).
  • Isoquinolines, like this compound, are known for their diverse pharmacological effects, including anti-inflammatory, antitumor, and analgesic properties. This could open doors to novel therapeutic applications.
  • The molecule can potentially serve as a template for synthesizing novel derivatives, inspiring ongoing research in drug design and development.

As a scientific community, our understanding of such intricate compounds illustrates the endless possibilities within organic chemistry to address complex health challenges. As we dive deeper into the molecular intricacies of this compound, one wonders: What new therapeutic avenues might we unlock?