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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
(4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

This compound is commonly found in its solid state at room temperature as a crystalline powder.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.00
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.00
General information
Molecular weight
413.10g/mol
Molar mass
413.1020g/mol
Density
1.3500g/cm3
Appearence

Noscapine typically appears as a white crystalline powder.

Comment on solubility

Solubility of (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of the compound C22H23NO7 is influenced by its complex structure and functional groups. Understanding the solubility can be summarized with the following considerations:

  • Polar and Non-polar Interactions: The presence of the methoxy (-OCH3) group enhances its polar characteristics, likely promoting solubility in polar solvents such as water or alcohols.
  • Hydrogen Bonding: The hydroxyl (-OH) group in the structure is capable of forming hydrogen bonds, which can increase solubility in polar solvents while limiting solubility in non-polar solvents.
  • Hydrophobic Regions: The bulky hydrophobic portions of the molecule may hinder its solubility in water, suggesting that it may be more soluble in organic solvents.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature, which should be taken into account during experiments.

In summary, while the exact solubility of C22H23NO7 in various solvents may need to be empirically determined, we can anticipate a better solubility in polar solvents due to its functional groups, despite potential hydrophobic hindrances present in its structure.

Interesting facts

Interesting Facts about (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This compound, with a complex and intriguing structure, represents a fascinating area of study within organic chemistry. Known for its unique stereochemistry, it features multiple chiral centers that contribute to its potential pharmacological properties. Here are some key points to consider:

  • Structural Diversity: The compound's intricate framework includes a methanobenzofuro and isoquinoline moiety, which are known to exhibit a variety of biological activities.
  • Pharmaceutical Potential: Compounds of this nature have been investigated for their effects on the central nervous system, making them relevant in the development of new therapeutic agents.
  • Natural Occurrence: Many similar isoquinoline derivatives are found in nature, particularly in plants, suggesting a rich source for natural product chemistry.
  • Synthetic Challenges: The synthesis of such complex molecules requires advanced techniques in organic synthesis, often employing multi-step reactions to achieve the desired stereochemistry.
  • Research Implications: Studies involving this compound could lead to discoveries in medicinal chemistry, opening avenues for developing new methods of treatment for various conditions.

In summary, (4S,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol serves as a remarkable example of how complex organic molecules can play significant roles in science and medicine. Its intriguing structure and potential applications make it a compound of interest for further exploration and study.