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Codeine

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Identification
Molecular formula
C18H21NO3
CAS number
76-57-3
IUPAC name
(4S,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
State
State

At room temperature, codeine is in a solid state. It is typically processed and mixed to form tablets or as a syrup when used medicinally.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
299.36g/mol
Molar mass
299.3640g/mol
Density
1.2930g/cm3
Appearence

Codeine is a white or slightly yellow crystalline powder. It appears as small, silky crystals that are usually odorless and have a bitter taste. It is typically used in its base form or as a phosphate or sulfate salt.

Comment on solubility

Solubility of (4S,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol

The solubility of complex organic compounds such as (4S,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol can often be influenced by various factors. Understanding its solubility characteristics is essential for applications in pharmaceuticals and biochemistry. Here are key considerations:

  • Polarity: The presence of hydroxyl groups (-OH) can enhance solubility in polar solvents like water, while hydrophobic structures may lead to greater solubility in organic solvents such as ethanol or acetone.
  • Hydrogen Bonding: Molecules capable of forming hydrogen bonds often show increased solubility in water. The hydroxyl groups likely allow for intermolecular interactions with water molecules.
  • Molecular Size: Larger molecular structures can hinder solubility due to steric effects, limiting the ability to fit into the lattice of a solvent.
  • pH Dependence: The solubility of compounds with acidic or basic functional groups can vary significantly with pH, affecting ionization and membrane permeability.

In conclusion, while the specific solubility of (4S,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol requires empirical measurement, understanding the factors influencing solubility can provide valuable insights for its pharmaceutical applications.

Interesting facts

Interesting Facts About (4S,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol

This compound, with its complex structure and unique functionality, belongs to a fascinating class of organic compounds known as alkaloids. Alkaloids are naturally occurring chemical compounds that mainly contain basic nitrogen atoms and are known for their physiological effects on humans and animals. This particular compound has garnered attention due to its potential medicinal properties.

Key Highlights:

  • Natural Origin: Many compounds like this one are derived from plants and fungi, which have been utilized in traditional medicine for centuries.
  • Biological Activity: Alkaloids are often studied for their various biological activities, including anti-inflammatory, analgesic, and even anticancer effects. This specific compound has shown promise in preliminary studies.
  • Stereochemistry: The stereochemical configuration of this compound is intricate, involving multiple chiral centers. This complexity often leads to varied biological activity depending on the spatial arrangement of atoms.
  • Research Interest: Due to its unique structure, it presents a worthwhile subject for ongoing research, particularly in the fields of organic synthesis and pharmacology.

As noted by chemists, "The configuration of the compound dictates not just its structure but its interaction with biological systems." This quote encapsulates the essence of why compounds like this are critical in drug development and understanding complex biological processes.

In the broader context of chemistry, studying such molecules enhances our comprehension of how molecular structure impacts function, thereby bridging the gap between chemistry and medicine. Research on compounds like (4S,4aS,7S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol helps not only to unveil new therapeutic agents but also to inspire the synthesis of novel compounds with improved efficacy and safety profiles.