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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
(4S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
State
State

Noscapine is typically found in a solid state as a crystalline powder at room temperature.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
345.70
Boiling point (Kelvin)
618.85
General information
Molecular weight
413.45g/mol
Molar mass
413.4520g/mol
Density
1.2740g/cm3
Appearence

Noscapine typically appears as a white to almost white powder.

Comment on solubility

Solubility of (4S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The solubility of the compound (4S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one can be quite complex and is influenced by various factors. Here are some key points to consider:

  • Polarity: This compound has both hydrophobic and hydrophilic groups, which affects its ability to dissolve in different solvents. The presence of a methoxy group generally indicates greater solubility in polar solvents.
  • Temperature Dependence: Like many organic compounds, solubility often increases with temperature. Therefore, assessing solubility at various temperatures could provide a clearer picture.
  • Solvent Interaction: The choice of solvent is crucial. It's likely to be soluble in solvents such as ethanol or dimethyl sulfoxide (DMSO), but may have reduced solubility in non-polar solvents like hexane.
  • pH Sensitivity: If the compound has functional groups that can ionize, its solubility may also vary with pH, influencing its overall behavior in aqueous solutions.

In summary, for (4S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, careful consideration of polarity, temperature, solvent choice, and pH is essential for understanding its solubility characteristics.


Interesting facts

Interesting Facts about the Compound

The compound known as (4S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one is a fascinating example of complex organic chemistry. Here are some intriguing points to consider:

  • Stereochemistry: The configuration of this compound is denoted by its stereochemical designations (4S, 7aR, 12bS), indicating that it possesses multiple chiral centers. This feature is crucial, as stereochemistry can significantly influence chemical reactivity and biological activity.
  • Natural Products: Structurally related compounds are often found in nature and can exhibit a range of biological activities. Compounds like this one have been studied for their potential medicinal properties, including their effects on various diseases.
  • Functional Groups: This compound contains multiple functional groups, enhancing its chemical reactivity. For example, the presence of the methoxy group (-OCH3) can influence solubility and reactivity, playing a vital role in its potential applications.
  • Applications in Drug Development: Due to its intricate structure, this compound could serve as a lead structure in pharmaceutical development. Research into similar compounds has yielded derivatives with promising anti-cancer and anti-inflammatory properties.
  • Complex Synthesis: The synthesis of such compounds poses challenges and usually requires multi-step processes involving advanced organic synthesis techniques. This complexity makes the study of their synthesis particularly exciting for chemistry students and professionals.

In conclusion, the structural complexity and potential biological significance of (4S,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one underscore its importance in the field of organic chemistry. As research in this area continues, we may uncover even more about the therapeutic potentials of such unique compounds.