Skip to main content

Norepinephrine

ADVERTISEMENT
Identification
Molecular formula
C8H11NO3
CAS number
51-41-2
IUPAC name
5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol
State
State

At room temperature, norepinephrine is typically in a solid state, appearing as a crystalline substance.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
169.18g/mol
Molar mass
169.1780g/mol
Density
1.2580g/cm3
Appearence

Norepinephrine appears as a white to off-white, crystalline powder. It is very hygroscopic and tends to oxidize, making it necessary to store in conditions that limit the exposure to air and moisture. The presence of air and/or light can cause discoloration and degradation of the compound.

Comment on solubility

Solubility of 5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol

The solubility characteristics of the compound 5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol (C8H11NO3) play a pivotal role in its application and behavior in various environments. Here are some insights into its solubility:

  • Polarity: The presence of hydroxyl groups (-OH) in the structure typically increases polarity, suggesting enhanced solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the compound to engage in hydrogen bonding likely contributes to its solubility, facilitating interaction with other polar molecules.
  • Alkyl Groups: The isopropylamino group adds a hydrophobic character, which may affect overall solubility in non-polar solvents, potentially limiting it in such environments.
  • Solvent Dependency: Expect varying degrees of solubility in different solvents, which can depend on temperature and the presence of electrolytes or other solutes.

In conclusion, while solubility can be influenced by multiple factors, it's important to remember that it is best evaluated under specific conditions. As they say, "The right conditions make all the difference!"

Interesting facts

Interesting Facts About 5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol

This fascinating compound, commonly referred to as a derivative of isopropylaminoethyl benzene diol, demonstrates a unique structure that is significant in the field of medicinal chemistry. Here are some captivating points about this compound:

  • Pharmacological Significance: Compounds similar to this one often exhibit biological activity, being explored for their roles in treating various health conditions, particularly in neuropharmacology.
  • Structure-Activity Relationship (SAR): Understanding how the different functional groups within this molecule affect its activity can provide insights into drug design and development.
  • Potential Applications: Research indicates that such compounds may have implications in the treatment of psychiatric disorders, with the isopropylamino moiety potentially enhancing binding affinity to specific receptors.
  • Chiral Centers: The presence of chiral centers in the structure indicates that enantiomers could exhibit different biological activities, which is a vital consideration in drug formulation.
  • Synthetic Pathways: The synthesis of this compound involves multi-step organic reactions, showcasing the intricate process of creating pharmaceuticals in the lab.

As a scientist, exploring the nuances of compounds such as 5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol not only expands our understanding of chemical properties but also opens doors to innovative therapeutic solutions.


In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." Exploring such compounds allows us to foster a myriad of ideas in the ever-expanding field of medicinal chemistry.

Synonyms
metaproterenol
ORCIPRENALINE
586-06-1
Alupent
Orciprenalina
Orciprenalinum
Orciprenalinum [INN-Latin]
Orciprenalina [INN-Spanish]
Orciprenaline [INN]
Prometa
Orciprenaline (INN)
CCRIS 9017
5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol
Orciprenaline [INN:BAN]
EINECS 209-569-1
(RS)-1-(3,5-Dihydroxyphenyl)-2-isopropylaminoethanol
BRN 2807247
CHEBI:6792
53QOG569E0
3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol
5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol
CHEMBL776
METAPROTERENOL [MI]
NSC-757089
1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-
METAPROTERENOL [VANDF]
ORCIPRENALINE [WHO-DD]
DTXSID8048529
NSC 757089
Benzyl alcohol, 3,5-dihydroxy-alpha-((isopropylamino)methyl)-
1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-
Orciprenalinum (INN-Latin)
Orciprenalina (INN-Spanish)
SR-01000075168
rac-5-(1-hydroxy-2-(isopropylamino)ethyl)benzene-1,3-diol
rac-5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol
Orciprenalin
5-(1-hydroxy-2-((propan-2-yl)amino)ethyl)benzene-1,3-diol
rac-5-(1-hydroxy-2-(propan-2-ylamino)ethyl)benzene-1,3-diol
rac-5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol
UNII-53QOG569E0
rac-orciprenaline
(RS)-orciprenaline
racemic orciprenaline
(+-)-orciprenaline
Spectrum_000925
Prestwick0_000505
Prestwick1_000505
Prestwick2_000505
Prestwick3_000505
Spectrum2_000096
Spectrum3_000492
Spectrum4_000044
Spectrum5_000952
SCHEMBL4270
Lopac0_000734
BSPBio_000429
BSPBio_001983
KBioGR_000507
KBioSS_001405
DivK1c_000645
SPECTRUM1500390
SPBio_000052
SPBio_002350
BPBio1_000473
GTPL7250
DTXCID9027996
CHEBI:82719
CHEBI:83329
HMS502A07
HY-B1276A
KBio1_000645
KBio2_001405
KBio2_003973
KBio2_006541
KBio3_001483
R03AB03
R03CB03
NINDS_000645
HMS1920L09
HMS2091D04
HMS3259J13
Pharmakon1600-01500390
1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-(9CI)
BDBM50295572
CCG-38914
NSC757089
AKOS022506181
DB00816
NC00651
SDCCGSBI-0050712.P005
IDI1_000645
NCGC00015655-02
NCGC00015655-03
NCGC00015655-04
NCGC00015655-05
NCGC00015655-06
NCGC00015655-14
NCGC00094718-01
NCGC00094718-02
NCGC00094718-03
SBI-0050712.P004
AB00052037
CS-0013668
NS00002953
C07144
D08300
EN300-142650
1-(3,5-Dihydroxyphenyl)-2-isopropylaminoethanol
AB00052037_09
AB00052037_10
L000678
Q416473
SR-01000075168-1
SR-01000075168-4
BRD-A07780951-001-06-3
BRD-A07780951-001-08-9
BRD-A07780951-065-09-2
BRD-A07780951-065-10-0
5-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,3-diol
5-(1-Hydroxy-2-isopropylamino-ethyl)-benzene-1,3-diol
5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol
5-[1-Hydroxy-2-(isopropylamino)ethyl]-1,3-benzenediol #
[2-(3,5-Dihydroxy-phenyl)-2-hydroxy-ethyl]-isopropyl-ammonium
1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-
3,5-Dihydroxy-.alpha.-((isopropylamino)methyl)benzyl alcohol
benzene, 1,3-dihydroxy-5-(1-hydroxy-2-isopropylamino)ethyl-
5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol, 6
Benzyl alcohol, 3,5-dihydroxy-.alpha.-((isopropylamino)methyl)-
[2-(3,5-Dihydroxy-phenyl)-2-hydroxy-ethyl]-isopropyl-ammonium (orciprenaline)
209-569-1