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Carvedilol

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Identification
Molecular formula
C24H26N2O4
CAS number
72956-09-3
IUPAC name
5-[1-hydroxy-2-(isopropylamino)ethyl]quinolin-8-ol
State
State

At room temperature, carvedilol is a solid.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
586.30
Boiling point (Kelvin)
859.45
General information
Molecular weight
406.49g/mol
Molar mass
406.5100g/mol
Density
1.2624g/cm3
Appearence

Carvedilol typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 5-[1-hydroxy-2-(isopropylamino)ethyl]quinolin-8-ol

The solubility of 5-[1-hydroxy-2-(isopropylamino)ethyl]quinolin-8-ol is an intriguing topic due to its unique chemical structure. This compound, which features both a quinoline moiety and an isopropylamino group, exhibits properties that affect its interactions with solvents.

Several factors play a role in determining the solubility of this compound:

  • Polarity: The presence of the hydroxyl group (-OH) increases polarity, enhancing solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents contributes to increased solubility.
  • Hydrophobic Regions: The quinoline ring can create hydrophobic interactions, which might limit solubility in highly polar environments.

Interestingly, one might conclude that this compound is likely to be soluble in polar organic solvents while exhibiting limited solubility in non-polar solvents. The balance of hydrophilic and hydrophobic characteristics makes it a compound of interest for researchers seeking to understand its behavior in different environments.

In summary, while solubility can vary based on concentration and temperature, it's essential to consider these factors for practical applications in various fields, particularly in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 5-[1-hydroxy-2-(isopropylamino)ethyl]quinolin-8-ol

5-[1-hydroxy-2-(isopropylamino)ethyl]quinolin-8-ol, a fascinating compound, showcases the intricate connection between organic chemistry and pharmaceutical applications. Here are some compelling insights regarding this compound:

  • Historical Significance: Quinoline derivatives have been known since the early 19th century and have played a pivotal role in the development of various pharmaceuticals, particularly in anti-malarial drugs.
  • Biological Activities: This compound possesses potential biological properties, including antimicrobial and antiproliferative activities, making it a subject of interest in medicinal chemistry.
  • Structure-Activity Relationship: The incorporation of the isopropylamino group significantly influences the compound's pharmacological profile, often enhancing its interaction with biological targets.
  • Synthesis and Reactivity: The synthetic pathways to produce this compound involve intriguing mechanisms that bond various functional groups, illustrating the creativity required in synthetic organic chemistry.

As with many organic compounds, studying 5-[1-hydroxy-2-(isopropylamino)ethyl]quinolin-8-ol offers a window into the vast landscape of medicinal chemistry, showcasing how small modifications in chemical structure can lead to substantial changes in activity and efficacy.

Moreover, its potential for further development in therapeutic applications reminds us of the enduring connection between structure and function in the world of chemical compounds.

Synonyms
Quinterenol
QUINPRENALINE
13757-97-6
Quinprenalina
Quinprenalinum
Chinprenalina
100EPZ8Y7G
8-Hydroxy-alpha-((isopropylamino)methyl)-5-quinolinemethanol
Quinprenaline [INN]
5-[1-hydroxy-2-(propan-2-ylamino)ethyl]quinolin-8-ol
NSC355081
Chinprenalina [DCIT]
Quinprenalinum [INN-Latin]
UNII-100EPZ8Y7G
Quinprenalina [INN-Spanish]
(+/-)-QUINTERENOL
1-(8-Hydroxy-5-chinolyl)-2-isopropylaminoethanol
orb2815522
CHEMBL2009119
SCHEMBL11538969
DTXSID70864439
NCI60_003198
NS00010546
5-(1-hydroxy-2-(isopropylamino)ethyl)-8-quinolinol
Q27251087
5-{1-Hydroxy-2-[(propan-2-yl)amino]ethyl}quinolin-8-ol
DL-5-(1-HYDROXY-2-ISOPROPYLAMINOETHYL)-8-HYDROXYQUINOLINE
5-Quinolinemethanol, 8-hydroxy-alpha-(((1-methylethyl)amino)methyl)-
8-HYDROXY-.ALPHA.-((ISOPROPYLAMINO)METHYL)-5-QUINOLINEMETHANOL
5-QUINOLINEMETHANOL, 8-HYDROXY-.ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-