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Nitazolam

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Identification
Molecular formula
C5H5N5O2S
CAS number
55188-19-7
IUPAC name
5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
State
State

At room temperature, Nitazolam is a solid substance.

Melting point (Celsius)
139.00
Melting point (Kelvin)
412.15
Boiling point (Celsius)
526.00
Boiling point (Kelvin)
799.15
General information
Molecular weight
238.24g/mol
Molar mass
238.2370g/mol
Density
1.5600g/cm3
Appearence

Nitazolam generally appears as a crystalline solid.

Comment on solubility

Solubility of 5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine

The solubility of 5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine is influenced by several factors, primarily its molecular structure and the presence of functional groups. This compound is characterized by a thiadiazole ring, which exhibits moderate interactions with solvent molecules.

Key Points on Solubility:

  • Polarity: Due to the presence of nitrogen atoms and potential hydrogen bonding sites, the compound may exhibit polar characteristics, enhancing its solubility in polar solvents like water.
  • Solvent Variability: It is likely to have differing solubility profiles in various solvents. For example, it may be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol compared to non-polar solvents.
  • Temperature Effects: As with many compounds, an increase in temperature typically results in increased solubility, making heating a common technique for dissolving solid compounds.

In summary, the solubility of 5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine is expected to be moderate and will be greatly affected by the choice of solvent and temperature conditions. Understanding these aspects is crucial for effective application in laboratory settings.

Interesting facts

Interesting Facts about 5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine

This unique compound, 5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine, is a fascinating subject of study in both medicinal chemistry and agricultural sciences. Its distinct structure comprises a thiadiazole ring fused with an imidazole moiety, enriching its potential applications. Here are some intriguing aspects worth noting:

  • Antimicrobial Activity: The compound has demonstrated significant antimicrobial properties, especially against various bacterial strains. This makes it a candidate for developing new antibiotics or antiseptics.
  • Antiparasitic Potential: Research has suggested that this compound may possess antiparasitic effects, particularly against protozoan parasites, highlighting its relevance in treating diseases like malaria.
  • Structure-Activity Relationship: The presence of the nitro group and the methyl substituent may enhance its biological activity. Scientists are continually exploring how variations in its structure can influence efficacy.
  • Role in Agriculture: Given its bioactivity, compounds like this one are often investigated for use as plant protection agents, potentially allowing for more sustainable agricultural practices.
  • Complex Synthesis: The synthesis of this compound involves several steps and requires careful control of reaction conditions. This complexity often necessitates advanced techniques in organic synthesis.

As with many compounds in chemistry, the study of 5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine exemplifies how chemical structures can dictate biological activity. With ongoing research, its therapeutic potential could lead to significant advancements in drug development and environmental applications. In the words of one prominent chemist, "The beauty of chemical compounds lies in their ability to surprise us with their potential."

Synonyms
megazol
19622-55-0
Nitroimidazole thiadiazole
1,3,4-Thiadiazol-2-amine, 5-(1-methyl-5-nitro-1H-imidazol-2-yl)-
VQ8UH664ZJ
NSC-265726
1,3,4-Thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-
CL 64 855
CL 64,855
2-Amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole
DTXSID50173298
DTXCID7095789
RefChem:156271
CL 64855
2-Amino-5-(1-methyl-5-nitroimidazol-2-yl)-1,3,4-thiadiazole
NSC265726
2-(2-amino-1,3,4-thiadiazol-5-yl)-1-methyl-5-nitroimidazole
5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
CCRIS 2480
NSC 265726
BRN 0619299
5-(1-methyl-5-nitroimidazol-2-yl)-1,3,4-thiadiazol-2-amine
UNII-VQ8UH664ZJ
CHEMBL423172
orb1699976
SCHEMBL11696315
VDZZTXBMKRQEPO-UHFFFAOYSA-N
GLXC-01575
AKOS040748898
CL-64855
DA-75397
NCI60_002137
HY-119480
CS-0068483
Q3304399
1,4-Thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-
5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
1,4-Thiadiazol-2-amine, 5-(1-methyl-5-nitro-1H-imidazol-2-yl)-
1,3,4-THIADIAZOL, 2-AMINO-5-(1-METHYL-5-NITRO-2-IMIDAZOLYL)-
2-AMINO-5-(1-METHYL-5-NITROIMIDAZOLE-2-YL)-1,3,4-THIADIAZOLE