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Lomitapide

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Identification
Molecular formula
C39H37NO6
CAS number
735854-90-7
IUPAC name
5-(1-piperidyl)naphtho[2,3-h]quinoline-7,12-dione
State
State

At room temperature, Lomitapide is typically in a solid state.

Melting point (Celsius)
90.00
Melting point (Kelvin)
363.15
Boiling point (Celsius)
660.15
Boiling point (Kelvin)
933.30
General information
Molecular weight
693.92g/mol
Molar mass
693.9150g/mol
Density
1.3390g/cm3
Appearence

In its pure form, Lomitapide appears as an off-white to pale-yellow solid.

Comment on solubility

Solubility of 5-(1-piperidyl)naphtho[2,3-h]quinoline-7,12-dione

The solubility of 5-(1-piperidyl)naphtho[2,3-h]quinoline-7,12-dione in various solvents is an intriguing subject, as it can significantly impact its functionality in chemical applications.

Here are some key factors affecting its solubility:

  • Polarity: The presence of the piperidyl group may influence the overall polarity of the compound, enhancing its solubility in polar solvents like methanol and water.
  • Hydrogen bonding: The nitrogen atom in the piperidyl ring can engage in hydrogen bonding, which may further increase solubility in protic solvents.
  • Hydrophobic interactions: The naphthoquinone moiety introduces hydrophobic characteristics, possibly leading to decreased solubility in nonpolar solvents such as hexane.

In general, the solubility of 5-(1-piperidyl)naphtho[2,3-h]quinoline-7,12-dione is likely to be higher in polar and protic solvents than in nonpolar environments, making it essential to consider the solvent when planning experiments or applications involving this compound.

Overall, understanding the solubility can allow chemists to predict how this compound will behave in different environments and how it can be best utilized in research or industrial applications.

Interesting facts

Interesting Facts about 5-(1-piperidyl)naphtho[2,3-h]quinoline-7,12-dione

This intriguing compound has garnered attention in the field of medicinal chemistry due to its unique structural features and potential biological activities. Here are some key highlights:

  • Structural Complexity: The compound features a naphthoquinone moiety, which is known for its reactivity and participation in various chemical reactions.
  • Biological Activity: Studies suggest that compounds with similar structures may exhibit anti-cancer properties, making this compound a subject of interest for researchers looking to develop new therapeutic agents.
  • Pharmacophoric Elements: The presence of the piperidyl group suggests that this compound could interact with biological targets such as enzymes and receptors, possibly leading to diverse pharmacological effects.
  • Versatile Reactivity: The quinone functionality is well-known for its ability to engage in electrophilic reactions, potentially allowing this compound to serve as an intermediate in the synthesis of more complex molecules.
  • Multi-domain Research: This compound finds applications across various disciplines, including organic chemistry, pharmacology, and chemical biology, making it a prime candidate for interdisciplinary studies.
  • Environmental Impact: Compounds like this one that contain quinone structures are studied for their roles in environmental processes, including oxidation-reduction reactions that contribute to ecological dynamics.

As research continues, there's potential for new discoveries related to the efficacy and applications of 5-(1-piperidyl)naphtho[2,3-h]quinoline-7,12-dione, illustrating the ever-evolving landscape of chemical science. The interplay between its chemical structure and biological activity underlines the importance of understanding complex molecules in the quest for innovative solutions in health and environment.

Synonyms
22817-48-7
AQ 229
BRN 0494660
5-(1-Piperidinyl)naphtho(2,3-h)quinoline-7,12-dione
5-22-13-00350 (Beilstein Handbook Reference)
Naphtho(2,3-h)quinoline-7,12-dione, 5-piperidino-
DTXSID50177372
Naphtho(2,3-h)quinoline-7,12-dione, 5-piperidino- (8CI)
NAPHTHO(2,3-h)QUINOLINE-7,12-DIONE, 5-(1-PIPERIDINYL)-