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Berberine

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Identification
Molecular formula
C20H18NO4
CAS number
6625-54-9
IUPAC name
5-(1,1-dimethylpentyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinoline
State
State

At room temperature, berberine is a solid. It generally appears as a dry, crystalline powder, making it easy to handle and measure for various applications.

Melting point (Celsius)
145.50
Melting point (Kelvin)
418.70
Boiling point (Celsius)
850.00
Boiling point (Kelvin)
1 123.00
General information
Molecular weight
336.44g/mol
Molar mass
336.4360g/mol
Density
1.3405g/cm3
Appearence

Berberine typically appears as a yellow crystalline powder. It is known for its intense yellow color and is often used as a dye. The compound's crystalline nature contributes to its slightly granular texture when observed closely.

Comment on solubility

Solubility of 5-(1,1-dimethylpentyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinoline

The solubility of 5-(1,1-dimethylpentyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinoline in various solvents can reveal important insights into its chemical behavior and potential applications. This compound, with a complex structure, tends to exhibit limited solubility in water, a common characteristic of many organic compounds that feature hydrophobic groups.

Key points to consider regarding its solubility include:

  • Polarity: The presence of both non-polar (dimethyl and pentyl groups) and polar (dioxolo part) regions may result in amphiphilic behavior, but overall, the compound may lean towards being non-polar.
  • Solvent interactions: It is likely to dissolve well in non-polar organic solvents such as hexane, toluene, or chloroform, while showing poor solubility in polar solvents like water or ethanol.
  • Temperature influence: An increase in temperature could enhance solubility in non-polar solvents, given the typical kinetic energy increase that allows molecules to overcome intermolecular forces.
  • Applications: Understanding the solubility profile is crucial for its use in pharmaceuticals, as it can affect bioavailability and distribution within biological systems.

In summary, the solubility of this compound is shaped by its intricate structure, and further exploration could provide valuable information on how to optimize its use in various chemical formulations.

Interesting facts

Interesting Facts about 5-(1,1-dimethylpentyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinoline

The compound 5-(1,1-dimethylpentyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinoline is a fascinating example of organic chemistry, representing a subclass of isoquinoline derivatives known for their rich pharmacological properties. Here are some intriguing aspects:

  • Structural Complexity: This compound features a unique structure that includes a dioxolo ring fused with an isoquinoline moiety. This complex arrangement enhances its potential biological activity.
  • Biological Significance: Isoquinoline derivatives are often the subject of extensive research due to their presence in various natural products and their potential use in medicinal chemistry. They have been investigated for their roles in treating diseases ranging from cancer to neurological disorders.
  • Synthetic Pathways: The synthesis of such specialized compounds can involve intricate multi-step processes. Understanding these pathways not only advances the development of new drugs but also enhances the appreciation of organic synthesis techniques.
  • Research Potential: The unique side chain of this compound may impart specific pharmacokinetic properties, making it a candidate for further study in pharmaceutical applications. Scientists are particularly interested in how variations in the side groups can affect biological activity.
  • Cross-Disciplinary Interest: Researchers in various fields—including medicinal chemistry, pharmacology, and biochemistry—are drawn to compounds like this one, highlighting the interconnectivity of chemical sciences.

In summary, 5-(1,1-dimethylpentyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinoline serves as a reminder of the intricate relationships between chemical structure and biological function. As scientists delve deeper into the study of such compounds, they uncover new avenues for innovation and therapeutic development.