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Berberine chloride

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Identification
Molecular formula
C20H18NO4Cl
CAS number
633-65-8
IUPAC name
5-(1,1-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride
State
State

At room temperature, berberine chloride is a solid. It is encountered typically in the form of a crystalline powder. The compound is soluble in water, reflecting its chloride salt form which enhances its hydrophilic properties.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
372.81g/mol
Molar mass
372.8100g/mol
Density
1.1785g/cm3
Appearence

Berberine chloride typically appears as a yellow crystalline powder. It is highly photostable, exhibiting a vibrant yellow hue that is a characteristic feature of this compound. It may also appear as fine yellow to orange needles or crystalline powder when isolated in a pure form.

Comment on solubility

Solubility of 5-(1,1-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride

The solubility of 5-(1,1-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride can be quite fascinating due to its unique structure and the presence of the positively charged isoquinolinium moiety. Understanding solubility for this compound involves considering several important factors:

  • Polarity: The presence of the dioxolo and isoquinolinium groups can influence the overall polarity of the compound, potentially enhancing solubility in polar solvents.
  • Solvent Interaction: This compound may exhibit varying solubility in different solvents, favoring polar aprotic solvents such as DMSO and DMF due to better interactions with its charged and polar regions.
  • Chloride Ion: The chloride ion can act as a counterion, enhancing solubility in aqueous environments, particularly where hydration of ions plays a crucial role.

It’s notable that solubility may also be affected by factors like temperature and pH. Nevertheless, in practice, a solvent’s ability to stabilize the charged species will primarily dictate the solubility outcomes. As a rule of thumb, one might quote, “like dissolves like,” emphasizing the importance of choosing a solvent that matches the compound’s molecular characteristics.

Overall, for 5-(1,1-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride, solubility is a multifaceted characteristic that holds the key to its potential applications in various chemical and pharmaceutical fields.

Interesting facts

Interesting Facts about 5-(1,1-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride

This compound, often referred to in abbreviated terms for convenience, showcases the fascinating complexity of organic chemistry. As a member of the isoquinoline family, it possesses unique structural attributes that contribute to its diverse chemical behavior and potential applications. Here are some interesting aspects of this compound:

  • Structure: The compound features a unique [1,3]dioxolo moiety, which is notable for its potential to participate in various chemical reactions, offering pathways for synthesis and modification.
  • Biological Activity: Many isoquinoline derivatives are known for their biological significance. Compounds in this category can exhibit a range of pharmacological activities, making them critical in drug discovery.
  • Ion Exchange: The presence of the chloride ion indicates that this compound can participate in ion exchange processes, which can be relevant in applications such as ion-selective electrodes or as catalysts in reactions.
  • Electronics and Materials Science: Compounds with similar structural features have shown promise in the field of organic electronics, potentially serving as semiconductors or components in organic light-emitting diodes (OLEDs).

The structural complexity of 5-(1,1-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride makes it a captivating subject for study in both synthetic and medicinal chemistry. As researchers delve deeper into the characteristics and behaviors of this compound, it may offer new insights into innovative materials and therapeutic agents:

  1. Research and Development: The exploration of such compounds can lead to groundbreaking advancements in chemistry and related fields.
  2. Environmental Considerations: When studying synthetic routes, understanding the environmental impact of these compounds is essential for sustainable chemistry practices.

In conclusion, the intricate nature of this compound not only enhances its scientific intrigue but also signifies its potential for transformative applications across various domains.

Synonyms
7-Methyl-5-tert-pentyl-1,3-dioxolo(4,5-g)isoquinoline hydrochloride
1,3-DIOXOLO(4,5-g)ISOQUINOLINE, 7-METHYL-5-tert-PENTYL-, HYDROCHLORIDE
16974-18-8