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GSK1016790A

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Identification
Molecular formula
C15H19N3O
CAS number
677746-25-7
IUPAC name
5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole
State
State

At room temperature, GSK1016790A is a solid. It is generally stable under standard laboratory conditions but should be handled with care to avoid moisture and light, which may affect its stability.

Melting point (Celsius)
140.50
Melting point (Kelvin)
413.65
Boiling point (Celsius)
567.15
Boiling point (Kelvin)
840.30
General information
Molecular weight
279.35g/mol
Molar mass
279.3470g/mol
Density
1.2450g/cm3
Appearence

GSK1016790A appears as a solid white powder that is crystalline in nature. Its texture is typical of fine chemical compounds used in research environments. The compound does not exhibit any significant odor.

Comment on solubility

Solubility of 5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole

The solubility of the compound 5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole can be quite complex due to its unique chemical structure. Key factors influencing its solubility include:

  • Polarity: Due to the presence of aromatic and heterocyclic components, the polarity of the molecule can affect its interaction with solvents. Polar solvents may promote solubility more effectively than non-polar ones.
  • Functional Groups: The isoxazole ring and the piperidine moiety contribute to the overall characteristics of the compound. These groups can engage in hydrogen bonding, which may enhance solubility in polar solvents.
  • Temperature: Typically, increased temperature can improve solubility. The thermal motion helps in breaking intermolecular forces that hold the solute molecules together.
  • pH Sensitivity: The solubility may vary with pH due to the potential ionization of the nitrogen atoms present in the piperidyl group.

In conclusion, **5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole** generally exhibits moderate solubility in organic solvents like ethanol and methanol while being less soluble in water. Proper evaluations should be performed under various conditions to ascertain the solubility limits for practical applications.

Interesting facts

Interesting Facts about 5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole

5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole is a compound that has garnered attention in the fields of medicinal chemistry and pharmacology due to its diverse biological activities and potential therapeutic applications. Here are some intriguing insights about this fascinating molecule:

  • Isoxazole Structure: This compound features an isoxazole ring, a five-membered heterocyclic structure containing both nitrogen and oxygen elements. Isoxazoles are known for their diverse chemical reactivity and are frequently utilized in drug development.
  • Pharmacological Potential: Compounds containing piperidine and pyridine groups typically demonstrate a range of pharmacological effects, including antidepressant, antitumor, and antimicrobial activities. The incorporation of these moieties in this compound suggests possible interactions with various biological targets.
  • Modulatory Effects: Research has indicated that similar compounds may serve as modulators of neurotransmitter systems, particularly in the central nervous system. This positions them as candidates for the treatment of conditions such as anxiety and depression.
  • Structural Versatility: The chemical features of this compound allow for modifications that can enhance activity or selectivity for specific biological targets. This structural versatility is essential for rational drug design.
  • Research Status: Ongoing studies continue to explore the mechanisms of action and efficacy of isoxazole derivatives, making this compound a subject of contemporary research interest.

As the scientific community delves deeper into the properties of 5-[2-(1-piperidyl)ethyl]-3-(2-pyridyl)isoxazole, it may lead to novel breakthroughs in therapeutic interventions, showcasing the significance of structural chemistry in drug discovery.