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Sertindole

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Identification
Molecular formula
C24H26ClFN4O
CAS number
106516-24-9
IUPAC name
5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole
State
State
Sertindole is in a solid state at room temperature, typically found as a crystalline powder.
Melting point (Celsius)
142.50
Melting point (Kelvin)
415.65
Boiling point (Celsius)
234.00
Boiling point (Kelvin)
507.15
General information
Molecular weight
440.58g/mol
Molar mass
440.5780g/mol
Density
1.2480g/cm3
Appearence

Sertindole appears as a white to off-white crystalline powder. It is relatively insoluble in water but soluble in organic solvents such as ethanol and DMSO (dimethyl sulfoxide).

Comment on solubility

Solubility of 5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole

The solubility of 5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole can be characterized by several key factors:

  • Polarity: This compound exhibits a moderate level of polarity due to the presence of the piperidyl group, which can influence its solubility in various solvents.
  • Solvent Interaction: Typically, compounds similar to this one tend to be more soluble in polar organic solvents such as methanol or dimethyl sulfoxide (DMSO) than in non-polar solvents.
  • Temperature Dependency: Solubility is often temperature-dependent; increasing the temperature can lead to a higher solubility for many organic compounds.
  • pH Influence: If the compound can ionize, the pH of the solution can significantly impact its solubility, particularly in aqueous environments.

In summary, while there is limited specific solubility data available for this compound, its characteristics suggest that it is likely to dissolve effectively in polar solvents while exhibiting lower solubility in non-polar ones. As always, for precise applications, it is essential to conduct experimental solubility assessments under specified conditions.

Interesting facts

Interesting Facts about 5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole

The compound 5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole is a fascinating member of the indole family, characterized by its complex ring structure and potential therapeutic applications. Here are some intriguing aspects to consider:

  • Chemical Structure: This compound features a unique bicyclic structure that includes a cyclohepta[b]indole moiety, making it structurally interesting for chemists and researchers alike.
  • Therapeutic Potential: Compounds similar to this one have been explored for their activity in the field of pharmaceuticals, especially in relation to neurological disorders and mental health treatments.
  • Intermolecular Interactions: The presence of the piperidine group suggests possible interactions with neurotransmitter receptors, highlighting its significance in medicinal chemistry and drug design.

As noted by researchers in the field, "The nuances of molecular interactions within complex chemical structures like cyclohepta[b]indole can offer profound insights into drug development." This highlights the importance of structures like that of 5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole in advancing medicinal chemistry.

In addition to its biological relevance, this compound serves as a compelling study subject for students in organic chemistry, providing an excellent example of how variation in chemical structure can lead to different biological activities. The exploration of such compounds is crucial, as they can lead to the discovery of new medications and therapies.

Overall, the study of 5-[2-(1-piperidyl)ethyl]-7,8,9,10-tetrahydro-6H-cyclohepta[b]indole exemplifies the intersection of structural chemistry and pharmacology, making it a significant topic of interest for both current and future chemical researchers.