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Coenzyme A

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Identification
Molecular formula
C21H36N7O16P3S
CAS number
85-61-0
IUPAC name
5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonatooxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-3-hydroxy-3-methyl-5-oxo-pentanoate
State
State

At room temperature, Coenzyme A is in a solid state. It is sensitive to both air and light, necessitating appropriate storage to prevent degradation. Typically, it is stored at low temperatures, away from moisture and light, to preserve its functional properties.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
767.54g/mol
Molar mass
767.5360g/mol
Density
0.6700g/cm3
Appearence

Coenzyme A is typically a white to off-white crystalline powder. It is hygroscopic, meaning it can absorb moisture from the surrounding environment, and thus, it is often handled in a dry environment to maintain its stability and effectiveness.

Comment on solubility

Solubility Characteristics of 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonatooxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-3-hydroxy-3-methyl-5-oxo-pentanoate

The solubility of the compound C21H36N7O16P3S can be characterized by its complex chemical structure, which suggests a range of solubility behaviors. Here are some key points to consider:

  • Hydrophilicity: The presence of multiple phosphoryl groups (P3) and hydroxyl groups (–OH) indicates a strong potential for hydrophilic interactions, which often enhances solubility in polar solvents such as water.
  • Hydrophobic regions: The tetrahydrofuran unit and the dimethyl-butanoyl moiety introduce hydrophobic character, which could limit solubility in highly polar environments.
  • pH dependence: The compound may exhibit variable solubility depending on the pH of the solution due to the ionizable groups present, particularly the ammonium (–NH2) functional groups.
  • Temperature sensitivity: Solubility can also be affected by temperature, where increased temperatures may enhance solubility due to increased molecular motion.

In summary, while this compound may display significant solubility in aqueous solutions, the extent can be influenced by factors such as pH and temperature. It is often essential to conduct experimental evaluations to determine the precise solubility characteristics and behavior in various solvents.

Interesting facts

Interesting Facts about 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonatooxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-3-hydroxy-3-methyl-5-oxo-pentanoate

This compound, with its intricately structured name, showcases the fascinating interplay of biological and chemical systems at a molecular level. Here are some engaging insights into this compound:

  • Biological Significance: It is known to be involved in various biological processes, serving crucial functions in cellular signaling pathways.
  • Phosphorylation: The presence of multiple phosphonate groups indicates its potential role in enzyme regulation and energy transfer, much like ATP (adenosine triphosphate).
  • Amino Group Influence: The 6-aminopurine moiety contributes to the compound's biological activity, which relates closely to nucleobases involved in DNA and RNA synthesis.
  • Structure Complexity: This compound's elaborate structure illustrates the vast complexity that chemical compounds can exhibit, often resulting in diverse biological interactions.
  • Potential Therapeutics: Compounds similar to this one have been explored for their therapeutic potential in treating various conditions related to metabolism and cellular function.

As students of chemistry or researchers, understanding such complex molecules not only enhances our knowledge of chemical interactions but also opens up new avenues in the development of pharmaceutical innovations. In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." Studying such diverse compounds allows us to explore these ideas and their implications in the realm of science.