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Coenzyme A

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Identification
Molecular formula
C21H36N7O16P3S
CAS number
85-61-0
IUPAC name
5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pent-3-enoic acid
State
State

At room temperature, Coenzyme A is typically in a solid state. It is stable under normal temperatures and pressures but should be kept dry to prevent decomposition.

Melting point (Celsius)
156.90
Melting point (Kelvin)
430.10
Boiling point (Celsius)
680.40
Boiling point (Kelvin)
953.60
General information
Molecular weight
767.54g/mol
Molar mass
767.5350g/mol
Density
1.3310g/cm3
Appearence

Coenzyme A appears as a white to off-white crystalline powder. It is hygroscopic in nature, meaning it can absorb moisture from the air, and should be stored in desiccated conditions to maintain its stability.

Comment on solubility

Solubility of 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pent-3-enoic acid

The solubility of 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pent-3-enoic acid (C21H36N7O16P3S) can be quite complex due to its intricate molecular structure. Here are some key points to consider:

  • The presence of multiple phosphate groups greatly enhances the compound's solubility in polar solvents, such as water.
  • Hydrophilic functional groups, such as amino and hydroxy groups, contribute positively to solubility by forming hydrogen bonds with solvent molecules.
  • Conversely, the presence of hydrophobic sections may create some resistance to solubility in non-polar solvents.

This compound’s solubility characteristics may result in varied behavior depending on the conditions. For instance:

  1. In aqueous environments, it is expected to dissolve readily due to the strong pull of water molecules interacting with its ionic and polar functional groups.
  2. In organic solvents, solubility may decrease significantly, highlighting the importance of solvent choice in practical applications.

In conclusion, the overall solubility of this compound is largely determined by its chemical nature and the environment, making it a fascinating subject for further investigation.

Interesting facts

Interesting Facts about 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pent-3-enoic acid

This compound is a fascinating entity in the realm of biochemical research, particularly due to its intricate structure and potential biological implications. Here are some noteworthy characteristics:

  • Complex Structure: It features a complex arrangement, integrating various functional groups that contribute to its unique properties and biological activities.
  • Biological Relevance: The presence of the 6-aminopurin-9-yl moiety suggests potential applications or roles in nucleic acid metabolism, impacting DNA and RNA synthesis.
  • Phosphate Groups: The multiple phosphoryl groups are critical for energy transfer; such structures are often seen in biochemically relevant molecules like ATP and GTP.
  • Custom Applications: Its intricate formulation indicates that it could serve specialized functions in pharmacology or biotechnology, potentially acting as a therapeutic agent.
  • Research Potential: Given its elaborate nature, researchers are likely investigating its mechanisms of action and therapeutic benefits, focusing on pathways that utilize purine derivatives.

In summary, the 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pent-3-enoic acid represents a rich area for exploration, as it may unlock new avenues in understanding cellular processes and developing innovative therapeutic applications. The layered complexity of its construction provides an exciting challenge and opportunity for scientists and students alike.

Synonyms
glutaconyl-coenzyme A
Coenzyme A, glutaconyl-
6712-05-6
Coenzyme A, S-(5-hydrogen 2-pentenedioate)
DTXSID20863932
5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxopent-3-enoic acid
NS00125777