Skip to main content

Coenzyme A (CoA)

ADVERTISEMENT
Identification
Molecular formula
C21H36N7O16P3S
CAS number
85-61-0
IUPAC name
5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pentanoic acid
State
State

At room temperature, Coenzyme A is typically a solid.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
767.53g/mol
Molar mass
767.5330g/mol
Density
1.3000g/cm3
Appearence

Coenzyme A is often a white to off-white powder or crystalline solid.

Comment on solubility

Solubility of 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pentanoic acid

The solubility of this complex compound, C21H36N7O16P3S, can be influenced by several factors, given its intricate structure and the presence of multiple functional groups. Here are some key points regarding its solubility:

  • Hydrophilicity vs. Hydrophobicity: The presence of multiple hydrophilic groups, such as hydroxyl (-OH) and phosphonate (-PO4H2) moieties, suggests potential for enhanced solubility in polar solvents like water.
  • pH Dependence: Solubility may vary significantly with pH due to the ionization of functional groups, particularly the phosphonate which can form zwitterions at physiological pH levels.
  • Solvent Interaction: The ability to dissolve this compound might also be favored in organic solvents like dimethyl sulfoxide (DMSO) or methanol, where solute-solvent interactions can stabilize its unique structure.
  • Temperature Effects: As with many chemical compounds, temperature may play a critical role; higher temperatures often increase solubility for solid compounds.

In conclusion, while it's challenging to provide a definitive solubility profile without empirical data, the structural features of this compound favor potential solubility in both aqueous and organic environments. Like many compounds of its nature, understanding the solubility will require careful assessment in varying conditions, underscoring the complexity of its chemical behavior.

Interesting facts

Interesting Facts about 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pentanoic acid

This fascinating compound is a remarkable example of the intricacies of organic chemistry and medicinal applications. Here are some interesting facts about it:

  • Complex Structure: The compound boasts a highly intricate molecular structure, which includes multiple functional groups such as amino, hydroxy, and phosphono. This diversity contributes to its unique biological properties.
  • Phosphorylation: The presence of several phosphoryl groups within its structure suggests potential roles in biochemical signaling processes. Phosphorylation is critical in numerous cellular functions, including metabolism and gene regulation.
  • Biological Relevance: With its association to 6-aminopurine, a nucleobase that can be found in pivotal biological processes like DNA and RNA synthesis, this compound may have implications in genetic research and biotechnology.
  • Potential Drug Development: The complexity of this compound makes it a candidate for further investigation in drug design, particularly in targeting specific enzymes or receptors due to its multifunctionality.
  • Synergistic Effects: The various moieties present may allow this compound to interact in multiple pathways, suggesting synergistic effects that could enhance its efficacy for therapeutic purposes.

In summary, 5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxo-pentanoic acid is more than just a simple compound; its complexity and potential make it a subject of continuous research and interest in the scientific community. The interplay between its structural components and biological functions embodies the beauty and challenge of chemistry in understanding life's molecular foundations.