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5-(2-Chloroethyl)-4-methylthiazole

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Identification
Molecular formula
C6H8ClNS
CAS number
13127-63-0
IUPAC name
5-(2-chloroethyl)-4-methyl-thiazole
State
State

At room temperature, 5-(2-Chloroethyl)-4-methylthiazole is typically in a liquid state. Its physical state can be influenced by ambient conditions such as temperature and pressure.

Melting point (Celsius)
-24.00
Melting point (Kelvin)
249.15
Boiling point (Celsius)
228.00
Boiling point (Kelvin)
501.15
General information
Molecular weight
149.64g/mol
Molar mass
149.6430g/mol
Density
1.1724g/cm3
Appearence

5-(2-Chloroethyl)-4-methylthiazole is generally a colorless to pale yellow liquid. It may show some chemical stability but can be prone to discoloration over time when exposed to the atmosphere.

Comment on solubility

Solubility of 5-(2-chloroethyl)-4-methyl-thiazole

5-(2-chloroethyl)-4-methyl-thiazole exhibits interesting solubility characteristics that are largely influenced by its chemical structure. As a heterocyclic compound, it is generally more soluble in polar solvents. Key points regarding its solubility include:

  • Solvent Dependency: This compound is typically soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).
  • Aqueous Solubility: Its solubility in water is limited, primarily due to the presence of hydrophobic thiazole rings and the chloroethyl group, which can hinder its ability to interact with water molecules.
  • Effect of Temperature: Like many organic compounds, solubility can increase with temperature, making it more soluble in hot solvents compared to cold ones.

It’s important to note that factors such as pH and ionic strength of the solvent can also influence solubility behavior. For instance, the presence of salts can either enhance or reduce solubility based on their specific interactions with the compound. Overall, understanding the solubility profile of 5-(2-chloroethyl)-4-methyl-thiazole is crucial for its applications in various chemical processes.

Interesting facts

Interesting Facts about 5-(2-chloroethyl)-4-methyl-thiazole

5-(2-chloroethyl)-4-methyl-thiazole is a fascinating compound that belongs to the class of thiazoles, which are sulfur-containing five-membered heterocycles. This particular compound showcases several intriguing aspects:

  • Biological Significance: Compounds similar to thiazoles have been extensively studied for their potential as therapeutic agents. They have demonstrated remarkable activities, such as antimicrobial, antifungal, and anti-inflammatory properties.
  • Chlorine Atom Influence: The presence of the chlorine atom in this compound can significantly affect its reactivity and biological activity, leading to variations in pharmacodynamics and pharmacokinetics in medicinal chemistry.
  • Synthesis Routes: The synthesis of thiazole derivatives often involves the use of well-established organic transformations. By altering the substituents on the thiazole ring, chemists can develop novel compounds with improved efficacy and safety profiles.
  • Industrial Applications: Beyond its potential medicinal uses, thiazole derivatives are also utilized in the agricultural sector, particularly as herbicides and fungicides, helping to protect crops from various pests and diseases.
  • Structure-Activity Relationship: In the study of thiazoles, researchers frequently examine the structure-activity relationships (SAR) to optimize the biological activity of these compounds, ensuring maximum effectiveness with minimal side effects.

In the words of renowned chemist John McCleverty, "Understanding the subtleties of heterocycles like thiazoles can lead to breakthroughs in drug design that we have yet to fully explore."
As students and scientists delve into the world of 5-(2-chloroethyl)-4-methyl-thiazole, they uncover potential health breakthroughs and novel applications, reinforcing the importance of this intriguing compound in contemporary chemistry.

Synonyms
Clomethiazole
533-45-9
Chlormethiazole
5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE
Clomethiazolum
5-(2-Chloroethyl)-4-methyl-1,3-thiazole
Chlorethiazol
Chlormethiazol
Emineurina
Chlorethiazole
Somnevrin
Clomethiazol
Clometiazole
Clometiazol
Chloraethiazol
Clometiazolo
Distraneurine
Clomethiazole [INN]
Clometiazolo [DCIT]
Chloro-S.C.T.Z.
Clometiazol [INN-Spanish]
Clomethiazolum [INN-Latin]
SCTZ [as edisylate]
WY 1485
Clomethiazole [INN:BAN]
EINECS 208-565-7
4-Methyl-5-(beta-chloroethyl)thiazole
Distraneurine (TN)
BRN 0114244
Clomethiazole (INN)
SCTZ (Salt/Mix)
DTXSID6022842
Heminevrin (Salt/Mix)
CLOMETHIAZOLE [MI]
CLOMETHIAZOLE [MART.]
CLOMETHIAZOLE [WHO-DD]
DTXCID802842
CLOMETHIAZOLE [NFLIS-DRUG]
4-27-00-00990 (Beilstein Handbook Reference)
4-Methyl-5-(.beta.-chloroethyl)thiazole
Clometiazol (INN-Spanish)
Clomethiazolum (INN-Latin)
SCTZ (AS EDISYLATE)
CLOMETHIAZOLE (MART.)
CLOMETHIAZOLE (NFLIS-DRUG)
clomAtiazole
N05CM02
208-565-7
pclitldotjtvdj-uhfffaoysa-n
Distraneurin
Thiazole, 5-(2-chloroethyl)-4-methyl-
C6H8ClNS
MFCD00868012
0C5DBZ19HV
NCGC00024842-02
CAS-533-45-9
UNII-0C5DBZ19HV
Tocris-0881
Biomol-NT_000260
SCHEMBL35223
MLS004754487
BPBio1_000815
CHEMBL315795
CHEBI:92875
BDBM234400
GLXC-06114
Tox21_110931
4-methyl-5-(2-chloroethyl)-thiazole
AKOS011348416
Tox21_110931_1
AB07565
DB06470
FC16096
SDCCGSBI-0633688.P001
5-(2-Chloro-ethyl)-4-methyl-thiazole
NCGC00024842-01
NCGC00024842-03
NCGC00024842-04
NCGC00024842-05
AC-33175
AS-13864
SMR002529479
SY101781
DB-071667
HY-129105
CS-0103601
NS00007179
EN300-60459
5-(2-Chloroethyl)-4-methyl-1,3-thiazole #
D07330
Q417178
BRD-K50422030-001-01-2
BRD-K50422030-001-05-3
BRD-K50422030-003-01-8
BRD-K50422030-003-02-6
Z945806150